ABSTRACT
A 21-year-old Indian who worked as a vaccinator in the smallpox programme developed an atypical case of variola major despite several previous, successful vaccinations. The clinical course of the disease was unusual, as there were two distinctly separate "crops" of smallpox. The disease began less than one month after a successful vaccination, which therefore gave the briefest period of protection recorded for this reliable immunization. The patient was found to have a virtually complete IgM deficiency with normal levels of circulating antibody against orthopox virus.
Subject(s)
Dysgammaglobulinemia/complications , Immunoglobulin M/deficiency , Occupational Diseases/immunology , Smallpox/immunology , Adult , Humans , Immunologic Techniques , Male , Smallpox/diagnosis , Smallpox/etiology , Smallpox Vaccine/therapeutic useSubject(s)
Radioisotopes , Tuberculosis, Meningeal/diagnosis , Bromine , Child , Child, Preschool , Humans , Infant , Infant, NewbornABSTRACT
The effects of long-term feeding of an adequate diet on the progressive changes in the biochemical parameters including gastrointestinal functions in children suffering from marasmus and kwashiorkor are presented. In both groups fasting bloos sugar, blood urea nitrogen, hemoglobin, serum total proteins and albumin at admission were significantly lower than in matched controls. These parameters improved after proper dietary therapy over a period of two years. The improvement in the biochemical parameters correlated with clinical and anthropological measurement. On admission, the gastrointestinal function as assessed by various tests was poor in both the groups. This returned to normal or near normal after nutritional rehabilitation. The return was much quicker for glucose and fat absorption than for lactose and d-xylose absorption. The rate of improvement in marasmus was slower than that in kwashiorkor.
