ABSTRACT
Raipur district is located in the South-eastern part of Madhya Pradesh state (Fig. 1). Phenotype and gene frequencies of blood groups A1A2BO, MN and RH among Gond, Kawar and Halba, three dominant tribes inhabiting the district, are reported.
Subject(s)
Blood Group Antigens/genetics , Child , Child, Preschool , Female , Gene Frequency , Genetic Markers , Humans , India , Male , PhenotypeABSTRACT
Prevalence of HBsAg was determined in 1314 sera obtained from 11 different tribal populations of five districts of Madhya Pradesh. Reversed passive haemagglutination assay was used for screening showed a HBsAg carrier rate of 2.99 to 21.54 per cent among the various tribes. Significant regional variation was also observed.
Subject(s)
Carrier State/epidemiology , Hepatitis B Surface Antigens/blood , Hepatitis B/epidemiology , Female , Humans , India/epidemiology , Male , Prevalence , Sex FactorsABSTRACT
Serological studies in 110 patients with systemic lupus erythematosus (SLE) have shown that autoantibodies to DNA and RNA had subspecificity to adenosine (30.9%), cytidine (79%), guanosine (44.5%), thymidine (20%) and uracil (56.3%). It was also observed that DNA antibodies are heterogenous and that antibody with specificity for both the native confirmation as well as exposed nucleoside of the denatured molecule were present in sera of most of the patients with SLE. There was also alteration in the pattern of antibody to nucleoside in some patients who were treated with steroids or immunosuppressive drugs.
Subject(s)
Autoantibodies/blood , Lupus Erythematosus, Systemic/immunology , Nucleosides/immunology , Antibody Specificity , DNA/immunology , Humans , RNA/immunologyABSTRACT
Twenty cases of systemic lupus erythematosus (SLE) in prepubertal children (less than 14 years of age) were seen over a period of 14 years. The male:female ratio was 1:2.3, and the mean age at onset was 9.37 years. Fever with joint involvement was the commonest presenting manifestation (60%), followed by nephrotic syndrome (25%). Notable clinical features included a high incidence of renal involvement (75%), significant hypertension (45%) and reversibility of acute renal failure (2 cases). The other organs and systems involved included: mucocutaneous manifestations (60%), cardiovascular system (30%), respiratory system (25%), neuropsychiatric manifestations (45%), and anemia (75%). Raynaud's phenomenon and thrombocytopenia were rare while leucopenia was not seen in a single patient. Immunological abnormalities noted were 100% positivity for antinuclear antibodies, and 87.5 and 75% positivity for antibodies to double-stranded and single-stranded DNA, respectively. Hypocomplementemia was seen in 75% of patients tested.
Subject(s)
Developing Countries , Lupus Erythematosus, Systemic/diagnosis , Adolescent , Adult , Antibodies, Antinuclear/analysis , Child , Child, Preschool , DNA/immunology , Female , Humans , India , Lupus Erythematosus, Cutaneous/diagnosis , Lupus Nephritis/diagnosis , Male , Middle AgedABSTRACT
The correlation between serum ionized calcium, serum total calcium and albumin corrected total calcium was investigated in a prospective multicentre investigation of 1,213 patients with suspected calcium metabolic disease. 31.0% of the patients were misclassified when serum total calcium was measured instead of serum ionized calcium. The diagnostic discrepancy between the two methods decreased with the calculation of albumin corrected total calcium or calculated ionized calcium (17.9%). On justing for the analytical error connected with the measurement of ionized calcium, 11.2% of the patients were still misclassified. It is not possible precisely to predict serum ionized calcium from the measurement of serum total calcium and we recommend measurement of serum ionized calcium in patients believed to have calcium metabolic disease.
Subject(s)
Calcium Metabolism Disorders/blood , Calcium/blood , Denmark , Humans , Multicenter Studies as Topic , Prospective Studies , Serum Albumin/analysisABSTRACT
The correlations between serum ionized calcium, serum total calcium, total calcium corrected for albumin and calculated ionized calcium were investigated in a prospective multicentre investigation of 1213 patients suspected of having calcium metabolic disease. Diagnostic discordance between serum total calcium and measured ionized calcium was found in 31% of the patients. With the calculation of albumin-corrected total calcium or calculated ionized calcium the discordance decreased to 17.9%. The diagnostic discordance which could be ascribed to the analytical imprecision (CV = 1.5%) amounted to only 6.7%. Although we found highly significant correlations between the parameters, a considerable scatter around the regression line made prediction of ionized calcium from albumin-corrected total calcium unreliable in many patients.
