ABSTRACT
After spontaneous regression of transplanted tumours, marked reduction in number of tumours was found when challenged with isogenic tumour cells. The ALS abrogates this effect. Tumour removal by surgical excision of limb and subsequent time scheduled challenge by tumour cells maximally suppress on the 10th day and continues up to the 42nd day the tumorogenic effect. Splenectomy has no effect if done before a day or 3 days after challenge but marked decrease in tumour development was seen when challenged on the 8th day after splenectomy. Amputation and splenectomy together potentiates tumour formation. Only in tumour extrication, does resistance develop up to the 42nd day from surgery. Challenging at a different site in mice with tumours, resulted in prolongation of the intervals of tumour formation. Challenge after surgical removal of tumour after a time lapse, results in marked reduction in number and size of tumours. Surgical tumour extrication after splenectomy and subsequent challenge on 11th day inhibited tumour formation. Whereas splenectomized tumour bearing mice when challenged at a heterosite did not develop resistance.
Subject(s)
Immunosuppression Therapy , Neoplasm Regression, Spontaneous/immunology , Sarcoma, Experimental/immunology , Sarcoma, Experimental/pathology , Spleen/immunology , Splenectomy , Animals , Mice , Neoplasm TransplantationSubject(s)
Mercuric Chloride/pharmacology , Organomercury Compounds/pharmacology , Sialic Acids/blood , Animals , Male , Perchlorates , RatsABSTRACT
Impact of chronic formaldehyde exposure in respect of route on behaviour was studied. Preconditioned (environmental) male albino rats (340-400 g) in 3 groups (n = 5) under 60 days oral and systemic exposure to 10 mg/kg/day HCHO were examined for their behavioural performance (i.e. short term memory) in Cook's apparatus. Twenty percent rats settled in grade III (unconditioned avoidance response) in the i.p. (i.e. systemic group) whereas in oral fed (HCHO route in drinking water) rats, 60% settled in grade II (conditioned avoidance response) at the end of sixty days.
Subject(s)
Behavior, Animal/drug effects , Formaldehyde/toxicity , Administration, Oral , Animals , Avoidance Learning/drug effects , Conditioning, Classical/drug effects , Injections, Intraperitoneal , Male , Memory, Short-Term/drug effects , Rats , Time FactorsSubject(s)
Acetylcholine/pharmacology , Biological Assay , Blood Pressure/drug effects , Acetylcholine/administration & dosage , Acetylcholine/blood , Animals , Injections, Intraperitoneal , Injections, Intravenous , Kymography , Methods , Pentobarbital/administration & dosage , Physostigmine/administration & dosage , Rats , Urethane/administration & dosageABSTRACT
Disseminated intravascular coagulation occurred in dogs given scorpion venom subcutaneously in doses of 3 mg./kg. body weight. Treatment with heparin reversed the coagulation abnormality of the syndrome and 10 out of 12 dogs survived. Necropsy findings in human patients stung by scorpions suggest that this syndrome also occurs in man.
