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1.
J Nanosci Nanotechnol ; 20(6): 3780-3784, 2020 06 01.
Article in English | MEDLINE | ID: mdl-31748076

ABSTRACT

Metal-Insulator-Metal (MIM) diodes used for infrared detection and frequency mixing since many decades and their development for energy harvesting applications in rectenna solar cell has accelerated a decade ago. In the horizon of these applications less complex fabrication methodology, accurate simulation methods and optimum material combination are required. Ultra-fast response of MIM diodes makes them a potential candidate for solar energy harvesting applications. Here in this work, the design and fabrication issues of MIM diode from simulation methodology based on insulating thickness properties to the fabrication methodology are discussed. MIM diode for Al-Al2O3-Ag combination is fabricated and characteristics such as I(V), asymmetry and non-linearity are reported.

2.
RSC Adv ; 9(15): 8262-8270, 2019 Mar 12.
Article in English | MEDLINE | ID: mdl-35518664

ABSTRACT

Printing of electronic devices on a paper substrate using 2D graphene-based ink is an opening gate to innovative applications, where devices would be biodegradable, eco-friendly and can be disposed of with negligible impact on the environment. A resistor is a key element of electronic devices and their application area depends upon its power rating and temperature coefficient of resistance (TCR). In this work, in house developed graphene ink is successfully utilized to fabricate a paper-based resistor using a bar coating technique. Dimensional patterning with precise known values of resistance is achieved using a laser with freedom of shape and size which has been explored for the first time on a paper substrate. The resistor has potential to handle ∼7 W power at room temperature with capacity to withstand up to 200 V which is the highest among reported printed resistors. A dual, low and high TCR is observed, correspondingly in cold (173 K to 300 K) and hot (300 K to 373 K) temperature regions with an activation energy E a of ∼8 meV for the cold region which is 375 percent lower than the hot region (∼30 meV). The dual TCR behaviour is of great importance for application as a stable resistor up to room temperature, and as a thermistor above room temperature.

3.
Clin Exp Pharmacol Physiol ; 38(7): 423-9, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21501211

ABSTRACT

1. Gallium arsenide (GaAs), a semiconductor, exerts toxicity as a result of its constitutive moieties; that is, gallium and arsenic that becomes dissociated after exposure. The present study focuses on reducing arsenic concentration from the target organs using monoesters of meso 2,3-dimercaptosuccinic acid (DMSA) either individually or in combination. 2. Animals were exposed to GaAs (0.0014 mol/kg, orally for 8 weeks) and then treated with monoisoamyl DMSA (MiADMSA), monocyclohexyl DMSA (MchDMSA) or monomethyl DMSA (MmDMSA) either individually (0.3 mmol/kg, orally) or in combination (0.15 mmol/kg each, orally) for five consecutive days. 3. GaAs exposure significantly inhibited blood δ-aminolevulinic acid dehydrogenase (ALAD), suggesting alterations in the heme synthesis pathway. Whereas a significant increase in blood, liver and kidney reactive oxygen species accompanied by an increase in lipid peroxidation points to the involvement of oxidative stress in GaAs toxicity. 4. GaAs also significantly disturbed glutathione metabolism. Hepatic and renal catalase activity decreased significantly, whereas hepatic and renal superoxide dismutase activity, as well as serum transaminases activity, showed marginal increase. Treatment with MiADMSA in combination with MchDMSA showed better therapeutic efficacy compared with other treatments in the aforementioned variables. 5. Co-administration of MiADMSA with MchDMSA provided better therapeutic effects, including reduction of arsenic burden, compared with all other treatments.


Subject(s)
Arsenic Poisoning/drug therapy , Arsenic/blood , Arsenicals/pharmacology , Gallium/pharmacology , Oxidative Stress/drug effects , Succimer/pharmacology , Aminolevulinic Acid/antagonists & inhibitors , Aminolevulinic Acid/blood , Animals , Arsenic Poisoning/blood , Arsenic Poisoning/metabolism , Catalase/metabolism , Copper/blood , Gallium/blood , Glutathione/metabolism , Heme/metabolism , Kidney/drug effects , Kidney/metabolism , Lipid Peroxidation/drug effects , Liver/drug effects , Liver/metabolism , Male , Rats , Rats, Wistar , Reactive Oxygen Species/metabolism , Succimer/analogs & derivatives , Superoxide Dismutase/metabolism , Transaminases/blood , Transaminases/metabolism , Zinc/blood
4.
Toxicol Appl Pharmacol ; 240(2): 236-44, 2009 Oct 15.
Article in English | MEDLINE | ID: mdl-19460394

ABSTRACT

Gallium arsenide (GaAs), an intermetallic semiconductor finds widespread applications in high frequency microwave and millimeter wave, and ultra fast supercomputers. Extensive use of GaAs has led to increased exposure to humans working in semiconductor industry. GaAs has the ability to dissociate into its constitutive moieties at physiological pH and might be responsible for the oxidative stress. The present study was aimed at evaluating, the principle moiety (Ga or As) in GaAs to cause neurological dysfunction based on its ability to cause apoptosis, in vivo and in vitro and if this neuronal dysfunction translated to neurobehavioral changes in chronically exposed rats. Result indicated that arsenic moiety in GaAs was mainly responsible for causing oxidative stress via increased reactive oxygen species (ROS) and nitric oxide (NO) generation, both in vitro and in vivo. Increased ROS further caused apoptosis via mitochondrial driven pathway. Effects of oxidative stress were also confirmed based on alterations in antioxidant enzymes, GPx, GST and SOD in rat brain. We noted that ROS induced oxidative stress caused changes in the brain neurotransmitter levels, Acetylcholinesterase and nitric oxide synthase, leading to loss of memory and learning in rats. The study demonstrates for the first time that the slow release of arsenic moiety from GaAs is mainly responsible for oxidative stress induced apoptosis in neuronal cells causing behavioral changes.


Subject(s)
Apoptosis/drug effects , Arsenic Poisoning/etiology , Behavior, Animal/drug effects , Gallium/toxicity , Nerve Degeneration/chemically induced , Neurons/drug effects , Acetylcholinesterase/metabolism , Animals , Animals, Newborn , Arsenic Poisoning/metabolism , Arsenic Poisoning/pathology , Arsenic Poisoning/physiopathology , Arsenicals , Cells, Cultured , Cerebral Cortex/drug effects , Cerebral Cortex/pathology , Cerebral Cortex/physiopathology , Dose-Response Relationship, Drug , Glutathione Peroxidase/metabolism , Glutathione Transferase/metabolism , Hippocampus/drug effects , Hippocampus/pathology , Hippocampus/physiopathology , Learning/drug effects , Male , Memory/drug effects , Mitochondria/drug effects , Mitochondria/metabolism , Nerve Degeneration/metabolism , Nerve Degeneration/pathology , Nerve Degeneration/physiopathology , Neurons/metabolism , Neurons/pathology , Nitric Oxide/metabolism , Nitric Oxide Synthase/metabolism , Oxidative Stress/drug effects , Rats , Rats, Wistar , Reactive Oxygen Species/metabolism , Superoxide Dismutase/metabolism
5.
Environ Toxicol Pharmacol ; 28(1): 140-6, 2009 Jul.
Article in English | MEDLINE | ID: mdl-21783994

ABSTRACT

Gallium arsenide (GaAs), an inter-metallic semiconductor, known to exhibit superior optical and electronic properties compared to silicon, promotes its use in semiconductor industries. Extensive use of GaAs will inevitably lead to an increase in the exposure of workers manufacturing these products. Antioxidants are exogenous or endogenous compounds acting in several ways, including scavenging reactive oxygen species (ROS) or their precursors, inhibiting ROS formation, and binding metal ions needed for the catalysis of ROS generation. In the present study we investigated the protective efficacy of α-lipoic acid, quercetin and captopril individually against gallium arsenide exposure. Co-administration of α-lipoic acid with GaAs was most effective in reducing GaAs induced inhibition of blood δ-aminolevulinic acid dehydratase (ALAD) activity, liver, kidney and brain reduced glutathione (GSH) level and elevation of oxidized glutathione (GSSG). Captopril, on the other hand was effective in reducing thiobarbituric acid reactive substance (TBARS) levels, while quercetin reduced ROS in liver and kidney. The results suggest comparatively better preventive efficacy of concomitant α-lipoic acid administration during Gallium arsenide exposure compared to quercetin and captopril in preventing GaAs induced oxidative stress.

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