1.
BMJ Case Rep
; 20122012 Jun 21.
Article
in English
| MEDLINE
| ID: mdl-22729340
ABSTRACT
A 59-year-old Caucasian gentleman presented with malaise, fatigue and proximal muscle weakness. He had history of long-standing roseate psoriasis treated with topical clobetasol propionate (dermovate). On admission, he had significant postural hypotension, and hypercalcaemia. Endocrinological investigation revealed hypercalcaemia, a serum cortisol of <30 nmol/l, a flat short synacthen test and undetectable adrenocorticotropic hormone. He was treated with hydrocortisone. The abrupt withdrawal of the topical steroids by the patient precipitated the addisonian crisis. Further enquiry documented inappropriate oral administration of clobetasol for more than 10 years in addition to prescribed topical usage.
Subject(s)
Adrenal Insufficiency/chemically induced , Clobetasol/adverse effects , Glucocorticoids/adverse effects , Self Medication/adverse effects , Adrenal Insufficiency/complications , Adrenal Insufficiency/drug therapy , Clobetasol/administration & dosage , Glucocorticoids/administration & dosage , Humans , Hydrocortisone/therapeutic use , Hypercalcemia/etiology , Male , Middle Aged , Psoriasis/drug therapy
2.
Ann Saudi Med
; 24(5): 374-7, 2004.
Article
in English
| MEDLINE
| ID: mdl-15573853