Reading the mind in the eyes in PTSD: Limited Moderation by the presence of a service dog.

Persons with posttraumatic stress disorder (PTSD) frequently experience relationship failures in family and occupational domains resulting in loss of social supports. Prior research has implicated impairments in social cognition. The Reading the Mind in the Eyes Test (RMET) measures a key component of social cognition, the ability to infer the internal states of other persons based on features of the eyes region of the face; however, studies administering this popular test to persons with PTSD have yielded mixed results. This study assessed RMET performance in 47 male U.S. military Veterans with chronic, severe PTSD. Employing a within-subjects design that avoided selection biases, it aimed specifically to determine whether components of RMET performance, including accuracy, response latency, and stimulus dwell time, were improved by the company of a service dog, an intervention that has improved social function in other populations. RMET accuracies and response latencies in this PTSD sample were in the normal range. The presence of a familiar service dog did not improve RMET accuracy, reduce response latencies, or increase dwell times. Dog presence increased the speed of visual scanning perhaps consistent with reduced social fear.

Comparison of the Word Memory Test and the Test of Memory Malingering in detecting invalid performance in neuropsychological testing.

Given the prevalence of compensation seeking patients who exaggerate or fabricate their symptoms, the assessment of performance and symptom validity throughout testing is vital in neuropsychological evaluations. Two of the most commonly utilized performance validity tests (PVTs) are the Word Memory Test (WMT) and the Test of Memory Malingering (TOMM). While both have proven successful in detecting invalid performance, some studies suggest greater sensitivity in the WMT relative to the TOMM. To improve upon previous research, this study compared performance in individuals who completed both the WMT and TOMM during a neuropsychological evaluation. Participants included 268 cases from a clinical private practice consisting of primarily disability claimants. One-way multivariate analysis of variance (MANOVA) compared neuropsychological performance of participants who passed both PVTs (n = 198) versus those who failed the WMT but passed the TOMM (n = 70). Global suppression of neuropsychological scores was found for participants who failed the WMT but passed the TOMM, as well as more psychiatric symptoms reported on questionnaires, relative to those who passed both PVTs. These findings suggest that those passing the TOMM but failing the WMT demonstrated performance invalidity, which illustrates the WMT's enhanced sensitivity.

Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease.

Recent evidence has advanced our understanding of the function of sleep to include removal of neurotoxic protein aggregates via the glymphatic system. However, most research on the glymphatic system utilizes animal models, and the function of waste clearance processes in humans remains unclear. Understanding glymphatic function offers new insight into the development of neurodegenerative diseases that result from toxic protein inclusions, particularly those characterized by neuropathological sleep dysfunction, like Parkinson's disease (PD). In PD, we propose that glymphatic flow may be compromised due to the combined neurotoxic effects of alpha-synuclein protein aggregates and deteriorated dopaminergic neurons that are linked to altered REM sleep, circadian rhythms, and clock gene dysfunction. This review highlights the importance of understanding the functional role of glymphatic system disturbance in neurodegenerative disorders and the subsequent clinical and neuropathological effects on disease progression. Future research initiatives utilizing noninvasive brain imaging methods in human subjects with PD are warranted, as in vivo identification of functional biomarkers in glymphatic system functioning may improve clinical diagnosis and treatment of PD.