[Rapid screening questionnaire based on clinical symptoms of patientswith benign paroxysmal positional vertigo].

Objective:To fomulate a rapid screening questionnaire for benign paroxysmal positional vertigo (BPPV) according to the symptoms of patients with BPPV. Method:A total of 276 patients with dizziness participated in this study, and 219 cases were included in the questionnaire validity evaluation except for 48 patients who participated in the revision of the questionnaire and 9 patients with inconsistent diagnosis. Subjects were divided into BPPV group and non-BPPV group according to the diagnostic criteria. ①All patients completed questionnaires based on positional dizziness, and the differences between the two groups were compared. ②Reliability test adopted test-retest reliability and Cronbach's α coefficient; content validity adopted expert judgment method, and structural validity adopted factor analysis. Result:①Reliability test: test-retest reliability was 0.945, Cronbach's α coefficient was 0.649. Validity test: KMO value was 0.720. Two factors were used with a characteristic root of higher than 0.9. The total cumulative contribution rate was 61.2%. ②Results of the questionnaire: The patients who developed dizziness when getting up/down or turning over in bed, accounted for 78(94.0%) in the BPPV group and 57(41.9%) in the non-BPPV group, with a statistical difference (P<0.01). In the cases of vertigo, there were 82 cases (98.8%) in the BPPV group and 96 cases (70.6%) in the non-BPPV group, with a statistical difference (P<0.01). There were 65 cases (78.3%) in the BPPV group and 53 cases (39.0%) in the non-BPPV group with dizziness/vertigo attack time less than 1 minute, with a statistical difference (P<0.01). Patients who had hearing loss or tinnitus during the dizziness episode accounted for 8(9.6%) in the BPPV group and 31 (22.8%) in the non-BPPV group, with a statistically difference (P<0.05). The patients with consciousness during dizziness episode were in 79 patients (95.2%) in the BPPV group and 128 patients (94.1%) in the non-BPPV group, with no statistical difference (P>0.05). Conclusion:This questionnaire has clinical applicability and can be used for rapid differential screening of BPPV in patients with dizziness.

[An analysis of biochemical markers of bone metabolism in patients with idiopathic benign paroxysmal positional vertigo].

Objective:To analyze the biochemical markers of bone metabolism in patients with idiopathic benign paroxysmal positional vertigo（iBPPV）. Method:The study included 38 patients with iBPPV. Thirty-two healthy persons were collected as control group. Routine history collection, physical examination, and diagnosis were recorded in case group. Both the case group and control group were assessed for the status of bone biochemical markers. Result:①Among the 38 patients with iBPPV, posterior semicircular canal BPPV in right ear（R-PC-BPPV）presented in 23 cases , left ear（L-PC-BPPV）in 9 cases, horizontal semicircular canal BPPV in right ear in 2 cases, and in left ear in 2 cases, horizontal semicircular canal cupulolithiasis in 2 cases. ②The value of osteocalcin(OC), 25 hydroxyvitamin D3ï¼»25(OH)D3ï¼½, amino terminal propeptide of type I procollagen (PINP) in case group were lower than the normal reference value, and also significantly lower than that in the control group,OC: t=-2.013, P=0.048; 25(OH)D3: t=-2.133，P=0.037; PINP: t=-2.615,P=0.011. There was no significant difference of ß-isomerized carboxy-terminal telopeptide of type I collagen (ß-CTx) between the case group and control group. ③The value of OC(t=-2.187，P=0.035), 25(OH)D3(t=-2.190，P=0.035) and PINP(t=-2.322，P=0.026) in patients lower than 50 years old were significantly lower than that in the control group. The difference of these biochemical markers between the case and control group was not significant when subjects were ≥50 years old. Conclusion:The biochemical markers of bone metabolism in patients with iBPPV are declined, especially in patients lower than 50 years old. There may be abnormal bone metabolism in iBPPV patients.