The Relationship Between Family Communication Quality and the Career Maturity of Adolescents: The Role of Time Perspective.

Purpose: Family communication quality is an influential factor of career maturity; however, very few studies have investigated the internal mechanisms underlying the relation between family communication quality and career maturity. This study investigated the mediating effect of time perspective on this relation, explored adolescents' time perspective profiles, and examined the relationships among family communication quality, career maturity, and time perspective profiles. Methods: In this one-year interval longitudinal study, adolescents (67.19% girls; aged 16.10-24.09 years; n = 442) reported parent-adolescent communication quality and time perspective at Time 1 and career maturity at Time 2. Results: The results showed that family communication quality positively predicted adolescents' career maturity, and this relation was mediated by adolescents' Present Fatalistic and Future time perspectives. Additionally, this study identified four time perspective profiles: balanced, moderate, negative, and risk-taking. We further examined how these time perspective profiles are associated with family communication quality and career maturity. The results showed that adolescents' perceptions of high-quality communication with their parents promoted them to endorse a balanced time perspective profile and protected them from endorsing a negative time perspective profile. Moreover, adolescents with a balanced time perspective profile exhibited better development in terms of career maturity, whereas those with a negative time perspective profile reported poor development in terms of career maturity. Conclusion: Present Fatalistic and Future time perspectives mediated the association between parent-adolescent communication quality and career maturity. Additionally, adolescents who engaged in high-quality communication with parents were more likely to endorse the balanced time perspective profile and less likely to adopt the negative time perspective profile; these adolescents were also more likely to achieve higher levels of career maturity. These findings highlight the necessity of improving parent-adolescent communication quality and guiding adolescents to establish a balanced time perspective profile with the goal of promoting adolescents' career maturity.

WITHDRAWN: Identification and Validation of Autophagy-related Genes in Sepsis-related Acute Kidney Injury (S-AKI) via Bioinformatics Analysis

Since the authors are not responding to the editor's requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the journal "Combinatorial Chemistry & High Throughput Screening".Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php. BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

Linkages Between Parenting Practices and Adolescents' Life Satisfaction: The Mediating Role of Resilience.

Background: Life satisfaction is a critical antecedent of adolescents' positive development in many domains. To promote adolescents to feel more satisfied with their lives, it is important to identify the factors influencing life satisfaction and to further investigate the inner mechanisms. The purpose of this research was to examine whether parenting practices were closely associated with life satisfaction among Chinese adolescents and whether these associations were mediated by adolescents' resilience. Methods: In this one-year interval longitudinal study, 353 students (50.7% girls) in Grade 7 and Grade 10 were recruited as participants. At the first wave of assessment, they reported parenting practices and resilience; at the second wave of assessment, they rated the level of life satisfaction. Results: The results of this study revealed that parental responsiveness, demandingness, and autonomy granting promoted adolescents' life satisfaction. Additionally, parental responsiveness and demandingness positively predicted adolescents' life satisfaction through the mediating effect of adolescents' resilience; however, resilience did not significantly mediate the relation between autonomy granting and adolescents' life satisfaction. Conclusion: Adolescents' resilience plays a mediating role in the relations between parental responsiveness and demandingness and adolescents' life satisfaction. The present study highlights the significance of providing adolescents with positive parenting practices and promoting adolescents' development of resilience to elevate their life satisfaction.

CTSB promotes sepsis-induced acute kidney injury through activating mitochondrial apoptosis pathway.

Background: Acute kidney injury is a common and severe complication of sepsis. Sepsis -induced acute kidney injury(S-AKI) is an independent risk factor for mortality among sepsis patients. However, the mechanisms of S-AKI are complex and poorly understand. Therefore, exploring the underlying mechanisms of S-AKI may lead to the development of therapeutic targets. Method: A model of S-AKI was established in male C57BL/6 mice using cecal ligation and puncture (CLP). The data-independent acquisition (DIA)-mass spectrometry-based proteomics was used to explore the protein expression changes and analyze the key proteomics profile in control and CLP group. The methodology was also used to identify the key proteins and pathways. S-AKI in vitro was established by treating the HK-2 cells with lipopolysaccharide (LPS). Subsequently, the effect and mechanism of Cathepsin B (CTSB) in inducing apoptosis in HK-2 cells were observed and verified. Results: The renal injury scores, serum creatinine, blood urea nitrogen, and kidney injury molecule 1 were higher in septic mice than in non-septic mice. The proteomic analysis identified a total of 449 differentially expressed proteins (DEPs). GO and KEGG analysis showed that DEPs were mostly enriched in lysosomal-related cell structures and pathways. CTSB and MAPK were identified as key proteins in S-AKI. Electron microscopy observed enlarged lysosomes, swelled and ruptured mitochondria, and cytoplasmic vacuolization in CLP group. TUNEL staining and CTSB activity test showed that the apoptosis and CTSB activity were higher in CLP group than in control group. In HK-2 cell injury model, the CTSB activity and mRNA expression were increased in LPS-treated cells. Acridine orange staining showed that LPS caused lysosomal membrane permeabilization (LMP). CA074 as an inhibitor of CTSB could effectively inhibit CTSB activity. CCK8 and Annexin V/PI staining results indicated that CA074 reversed LPS-induced apoptosis of HK-2 cells. The JC-1 and western blot results showed that LPS inhibited mitochondrial membrane potential and activated mitochondrial apoptosis pathway, which could be reversed by CA074. Conclusions: LMP and CTSB contribute to pathogenesis of S-AKI. LPS treatment induced HK-2 cell injury by activating mitochondrial apoptosis pathway. Inhibition of CTSB might be a new therapeutic strategy to alleviate sepsis-induced acute kidney injury.

Parent-Adolescent Communication Quality and Life Satisfaction: The Mediating Roles of Autonomy and Future Orientation.

BACKGROUND: Previous studies have suggested that family communication quality is an important factor that can influence adolescents' life satisfaction. However, relatively few studies have examined this relationship in the Chinese cultural context or explored the potential mechanisms underlying this relationship. Therefore, the purpose of this study was to investigate whether family communication quality is closely linked to Chinese adolescents' life satisfaction and whether this link was mediated by autonomy and future orientation. METHODS: This study recruited 442 Chinese college students (67.19% girls) as participants. Based on a longitudinal design, the participants reported family communication quality at Time 1 and reported autonomy, future orientation, and life satisfaction at Time 2. RESULTS: The results of correlation analysis showed the existence of a positive correlation between family communication quality, autonomy, future orientation, and life satisfaction. The mediation models showed family communication quality predicted adolescents' life satisfaction through the mediating effects of autonomy and future orientation. Furthermore, autonomy and future orientation not only independently mediated the relationship between family communication quality and life satisfaction but sequentially mediated this relationship. CONCLUSION: Autonomy and future orientation mediated the relationship between family communication quality and life satisfaction. The findings of the present study highlight the significance of elevating family communication quality and promoting adolescents' development of autonomy and future orientation to enhance their life satisfaction.

Parenting Practices, Family Obligation, and Adolescents' Academic Adjustment: Cohort Differences with Social Change in China.

This study examined possible changes in the functions of parenting practices across different historical time points in terms of the effects of parenting practices on adolescents' academic adjustment and their indirect effects via family obligation values. This study used a time-lagged design that recruited Chinese high school students in 2010 (N = 1,040) and 2018 (N = 1,302). Structured equation modeling revealed the total effects of acceptance/involvement and strictness/supervision on academic adjustment and their indirect effects through family obligation values were positive and statistically equivalent across cohorts. However, the indirect effect of psychological autonomy granting on academic adjustment through family obligation values was negative in 2010 (in rural) but was not statistically significant in 2018 (urban and rural). These findings indicate that along with the sociodemographic change toward Gesellschaft (e.g., more urbanized, wealthier, higher level of education), psychological autonomy granting tends to exert less negative influence on adolescents' adjustment in the later cohort.

Parenting Styles and Parent-Adolescent Relationships: The Mediating Roles of Behavioral Autonomy and Parental Authority.

The parent-adolescent relationship has been a classic research topic, and researchers have found that parenting styles (e.g., authoritative, authoritarian) are closely related to various qualities of parent-adolescent relationships (e.g., cohesion, conflict). However, little empirical work has addressed how these variables correlate with each other in mainland China, nor has prior research addressed internal psychological mechanisms. The present study investigated the associations between parenting styles and parent-adolescent relationship factors, examined the mediating effects of adolescents' expectations of behavioral autonomy and beliefs about parental authority, and explored whether adolescent gender moderated these effects. Results from a sample of 633 Chinese adolescents (7th grade: M age = 13.50 ± 0.62 years, 9th grade: M age = 15.45 ± 0.67 years, 11th grade: M age = 17.30 ± 0.75 years) suggested similar levels of parent-adolescent conflict frequency for all parenting styles. However, for parent-adolescent conflict intensity, youth of neglectful and authoritarian parents reported higher levels compared to those with indulgent parents. The highest levels of cohesion with both parents were reported by adolescents with authoritative parents, followed by indulgent, authoritarian and neglect parenting styles. Cohesion with mothers for youth with authoritative or indulgent mothers was higher for girls than boys. Adolescents' expectation for behavioral autonomy mediated the links between parenting style and conflict, whereas adolescents' beliefs about the legitimacy of parental authority mediated the links between parenting style and cohesion; some of these mediating effects differed by gender. Findings highlight the importance of studying potential effects of adolescents' values and attitudes within the family system in specific cultural contexts.