ABSTRACT
Out of 163 STEMI patients, 33 presented left ventricular remodeling (LVR) as assessed by multiple cardiac magnetic resonance (CMR) scans. LVR patients were identified as EarlyLVR (LVR occurring between baseline and 3â¯months) or LateLVR (LVR occurring between 3â¯months and one year), and matched to non-remodeler patients in term of age, gender, anterior infarction, baseline LV ejection fraction and infarct size. ST2 and NT-proBNP were measured at baseline and 3â¯months. Systolic wall stress (SWS) was calculated by CMR. At baseline, mean levels of ST2, NT-proBNP and SWS were 67.1⯱â¯54.1â¯ng/mL, 1529⯱â¯1702â¯ng/L and 17.9⯱â¯7.1 103â¯N·m-2, respectively, and did not differ among the groups. At 3â¯months, EarlyLVR patients presented significant higher ST2, NT-proBNP and SWS (31.6⯱â¯12.7â¯ng/mL, 1142⯱â¯1069â¯ng/L, 25.5⯱â¯9.7 103â¯N·m-2), compared to the corresponding non-remodelers (20.5⯱â¯8.6â¯ng/mL, 397⯱â¯273â¯ng/L, 18⯱â¯7.3 103â¯N·m-2; with pâ¯=â¯0.017, 0.040, and 0.036, respectively). LateLVR patients presented higher ST2 at 3â¯months than their non-remodelers (33.6⯱â¯15.9 versus 23.66⯱â¯8.7â¯ng/mL, pâ¯=â¯0.046), while NT-proBNP and SWS were not different between groups at both timepoints.
Subject(s)
Interleukin-1 Receptor-Like 1 Protein/blood , ST Elevation Myocardial Infarction/blood , ST Elevation Myocardial Infarction/diagnostic imaging , Ventricular Remodeling/physiology , Aged , Cohort Studies , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Prospective Studies , Time FactorsABSTRACT
AIMS: To describe and illustrate the main applications of phase-contrast flow quantification in cardiovascular imaging. CONCLUSION: Phase-contrast velocimetry sequences provide an accurate, reliable, reproducible and non-invasive study of blood flow, information which is sometimes not available from other investigation methods. The haemodynamic information obtained from these complement MRI angiography images. They appear to have a range of clinical applications, firstly improving pathophysiological understanding but also contributing to the treatment and follow-up strategy after surgical or endovascular treatment.