ABSTRACT
Aim of this study was to analyze the karyological indicators in exfoliated cells in patients with cancer of the gastrointestinal tract. There was revealed statistically significant (p < 0.01) increase of all parameters in buccal and nasal epithelium in such kind of patients compared to healthy persons. These changes were systemic in nature and reflected the general state of the organism.
Subject(s)
Gastrointestinal Neoplasms/genetics , Gastrointestinal Neoplasms/therapy , Karyotype , Karyotyping , Adult , Aged , Colorectal Neoplasms/genetics , Colorectal Neoplasms/therapy , Cytogenetic Analysis , Female , Gastrointestinal Neoplasms/pathology , Humans , Male , Middle Aged , Mouth Mucosa/pathology , Stomach Neoplasms/genetics , Stomach Neoplasms/therapyABSTRACT
Administration of an immunomodulator, galavit, for stage II-III non-small lung cancer along with standard therapy was followed by immunological vigor improvement by the end of the course. CD3, CD4, IgA, IgM and IgG indices were normal in more than 80% of the study group by day 51 after surgery; CD8, CD20 and HLA-DR--in more than 50%; CD16--in 45.2%. In control, by day 51, normal IgG and HLA-DR levels were reported in 60%. The remaining indices were normal in less than 50%. Our results point to immunological vigor improvement due to use of galavit. The drug is well tolerated, has neither side effects nor toxicity.
Subject(s)
Antigens, Neoplasm/blood , Carcinoma, Non-Small-Cell Lung/immunology , Immunologic Factors/therapeutic use , Lung Neoplasms/immunology , Phthalazines/therapeutic use , Adult , Aged , Antigens, CD20/blood , CD3 Complex/blood , CD4 Antigens/blood , CD8 Antigens/blood , Carcinoma, Non-Small-Cell Lung/pathology , Double-Blind Method , Female , HLA-DR Antigens/blood , Humans , Immunoglobulin A/blood , Immunoglobulin G/blood , Immunoglobulin M/blood , Immunologic Factors/pharmacology , Luminol/analogs & derivatives , Lung Neoplasms/pathology , Male , Middle Aged , Neoplasm Staging , Phthalazines/pharmacology , Receptors, IgG/bloodSubject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Breast Neoplasms/drug therapy , Pancreas/drug effects , Pancreatitis/chemically induced , Receptor, ErbB-3/biosynthesis , Adult , Aged , Aged, 80 and over , Amylases/blood , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/metabolism , Case-Control Studies , Chemotherapy, Adjuvant , Doxorubicin/administration & dosage , Doxorubicin/adverse effects , Doxorubicin/therapeutic use , Female , Humans , Lipase/blood , Middle Aged , Neoadjuvant Therapy , Paclitaxel/administration & dosage , Paclitaxel/adverse effects , Paclitaxel/therapeutic use , Pancreas/diagnostic imaging , Pancreas/enzymology , Pancreatitis/blood , Pancreatitis/diagnostic imaging , Pancreatitis/epidemiology , Retrospective Studies , UltrasonographyABSTRACT
The results of examination of 156 patients were used to consider whether radiation and endoscopic techniques might be used in the differential diagnosis of gastric ulcerations. The necessity of their complex use is shown. Evidence is provided for that the understanding of intramural changes at the site of ulceration should underlie the interpretation of visual changes in the gastric mucosa. An algorithm has been developed for the rational and effective use of radiation and endoscopic techniques in the differential diagnosis of gastric ulcerations. The algorithm is shown to be highly effective in the correct interpretation of the pattern of an identified ulceration (98.4% specificity). Ultrasound and computed tomographic semiotics of benign and malignant gastric ulcerations is presented.
Subject(s)
Gastroscopy , Stomach Neoplasms/diagnosis , Stomach Ulcer/diagnosis , Stomach/diagnostic imaging , Algorithms , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Radiography , Stomach Neoplasms/diagnostic imaging , Stomach Ulcer/diagnostic imaging , UltrasonographySubject(s)
Antineoplastic Agents/therapeutic use , Breast Neoplasms/drug therapy , Breast/diagnostic imaging , Breast Neoplasms/blood supply , Breast Neoplasms/diagnostic imaging , Chemotherapy, Adjuvant , Female , Humans , Microspheres , Sodium Pertechnetate Tc 99m , Technetium Tc 99m Aggregated Albumin , Tomography, Emission-Computed/methodsSubject(s)
Breast Neoplasms/drug therapy , Etoposide/administration & dosage , Etoposide/toxicity , Administration, Oral , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Cyclophosphamide/administration & dosage , Epirubicin/administration & dosage , Female , Humans , Injections, Intravenous , Lymphatic Metastasis , Middle Aged , Neoplasm Metastasis , Time FactorsABSTRACT
A procedure for obtaining microcirculation coefficient is described. It is based on the phenomenon of formation of a focus of radionuclide hyperfixation on scintigrams of tumor area due to embolization of its arterioles and precapillaries with radionuclide. The method was used in 26 breast cancer patients before neoadjuvant chemotherapy. A direct correlation between the microcirculation coefficient and degree of tumor-induced pathomorphosis of tumor cells was established. The coefficient values proved more or less predictive of tumor response to chemotherapy.
