ABSTRACT
Aim of this study was to analyze the karyological indicators in exfoliated cells in patients with cancer of the gastrointestinal tract. There was revealed statistically significant (p < 0.01) increase of all parameters in buccal and nasal epithelium in such kind of patients compared to healthy persons. These changes were systemic in nature and reflected the general state of the organism.
Subject(s)
Gastrointestinal Neoplasms/genetics , Gastrointestinal Neoplasms/therapy , Karyotype , Karyotyping , Adult , Aged , Colorectal Neoplasms/genetics , Colorectal Neoplasms/therapy , Cytogenetic Analysis , Female , Gastrointestinal Neoplasms/pathology , Humans , Male , Middle Aged , Mouth Mucosa/pathology , Stomach Neoplasms/genetics , Stomach Neoplasms/therapyABSTRACT
The cytological status, proliferation, and apoptosis of the buccal epithelium and the level of secretory immunoglobulin A were studied in 90 children living in a large ferrous metallurgy center (Tula). There were increases in the degree of cytogenetic impairments, a change in cell kinetic processes, and a reduction in local immunity in children in a more polluted area. There was a high significant correlation of karyological and immunological parameters with some chemical ambient air pollutants.
