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1.
The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity.
Fodor, W L; Rollins, S A; Bianco-Caron, S; Rother, R P; Guilmette, E R; Burton, W V; Albrecht, J C; Fleckenstein, B; Squinto, S P.
J Virol ; 69(6): 3889-92, 1995 Jun.
Article in English | MEDLINE | ID: mdl-7745740

ABSTRACT

The herpesvirus saimiri genome encodes a complement control protein homolog (CCPH). Stable mammalian cell transfectants expressing a recombinant transmembrane form of CCPH (mCCPH) or a 5'FLAG epitope-tagged mCCPH (5'FLAGmCCPH) conferred resistance to complement-mediated cell damage by inhibiting the lytic activity of human serum complement. The function of CCPH was further defined by showing that the mCCPH and the 5'FLAGmCCPH transfectants inhibited C3 convertase activity and effectively reduced cell surface deposition of the activated complement component, C3d.


Subject(s)
Complement C3-C5 Convertases/antagonists & inhibitors , Complement System Proteins/metabolism , Herpesvirus 2, Saimiriine/metabolism , Membrane Glycoproteins/physiology , Viral Proteins/physiology , Amino Acid Sequence , Base Sequence , DNA Primers , Humans , Membrane Glycoproteins/genetics , Molecular Sequence Data , Viral Proteins/genetics
2.
Primate terminal complement inhibitor homologues of human CD59.
Fodor, W L; Rollins, S A; Bianco-Caron, S; Burton, W V; Guilmette, E R; Rother, R P; Zavoico, G B; Squinto, S P.
Immunogenetics ; 41(1): 51, 1995.
Article in English | MEDLINE | ID: mdl-7528724

Subject(s)
Antigens, CD/genetics , Membrane Glycoproteins/genetics , Animals , Base Sequence , CD59 Antigens , DNA, Complementary , Humans , Molecular Sequence Data , Primates/genetics , Sequence Alignment , Sequence Homology, Nucleic Acid
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