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Bioorg Med Chem
; 21(11): 2999-3009, 2013 Jun 01.
Article
in English
| MEDLINE
| ID: mdl-23635904
ABSTRACT
A series of heterocyclic quinones based on benzofuran, benzothiophene, indazole and benzisoxazole has been synthesized, and evaluated for their ability to function as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumor cells. Overall, the quinones are excellent substrates for NQO1, approaching the reduction rates observed for menadione.