Intelligibility of Natively and Nonnatively Produced English Speech Presented in Noise to a Large Cohort of United States Service Members.

PURPOSE: A corpus of English matrix sentences produced by 60 native and nonnative speakers of English was developed as part of a multinational coalition task group. This corpus was tested on a large cohort of U.S. Service members in order to examine the effects of talker nativeness, listener nativeness, masker type, and hearing sensitivity on speech recognition performance in this population. METHOD: A total of 1,939 U.S. Service members (ages 18-68 years) completed this closed-set listening task, including 430 women and 110 nonnative English speakers. Stimuli were produced by native and nonnative speakers of English and were presented in speech-shaped noise and multitalker babble. Keyword recognition accuracy and response times were analyzed. RESULTS: General(ized) linear mixed-effects regression models found that, on the whole, speech recognition performance was lower for listeners who identified as nonnative speakers of English and when listening to speech produced by nonnative speakers of English. Talker and listener effects were more pronounced when listening in a babble masker than in a speech-shaped noise masker. Response times varied as a function of recognition score, with longest response times found for intermediate levels of performance. CONCLUSIONS: This study found additive effects of talker and listener nonnativeness when listening to speech in background noise. These effects were present in both accuracy and response time measures. No multiplicative effects of talker and listener language background were found. There was little evidence of a negative interaction between talker nonnativeness and hearing impairment, suggesting that these factors may have redundant effects on speech recognition. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.26060191.

Age Impacts Speech-in-Noise Recognition Differently for Nonnative and Native Listeners.

PURPOSE: The purpose of this study was to explore potential differences in suprathreshold auditory function among native and nonnative speakers of English as a function of age. METHOD: Retrospective analyses were performed on three large data sets containing suprathreshold auditory tests completed by 5,572 participants who were self-identified native and nonnative speakers of English between the ages of 18-65 years, including a binaural tone detection test, a digit identification test, and a sentence recognition test. RESULTS: The analyses show a significant interaction between increasing age and participant group on tests involving speech-based stimuli (digit strings, sentences) but not on the binaural tone detection test. For both speech tests, differences in speech recognition emerged between groups during early adulthood, and increasing age had a more negative impact on word recognition for nonnative compared to native participants. Age-related declines in performance were 2.9 times faster for digit strings and 3.3 times faster for sentences for nonnative participants compared to native participants. CONCLUSIONS: This set of analyses extends the existing literature by examining interactions between aging and self-identified native English speaker status in several auditory domains in a cohort of adults spanning young adulthood through middle age. The finding that older nonnative English speakers in this age cohort may have greater-than-expected deficits on speech-in-noise perception may have clinical implications on how these individuals should be diagnosed and treated for hearing difficulties.

Short-term retention of learning after rapid adaptation to native and non-native speecha).

Non-native, accented speech spoken by unfamiliar talkers can be challenging to recognize, but rapid improvements in perception are often observed after a short period of exposure. However, it is not clear whether these improvements are retained over multiple sessions. Stimulus variability facilitates learning for non-native speech, so it is possible it may also induce increased retention of learning for speech produced with an unfamiliar accent. In this paper, we conduct a retrospective analysis of a dataset well suited to examine learning of non-native English speech on both a within-session and across-session basis. During data collection, participants completed a protocol involving recognition of matrix sentences recorded by native and non-native talkers with different first languages. Listeners completed the protocol in a self-paced approach, including 15 blocks of 50 trials over 4-7 days, separated by an average of 1-2 days. Learning was strongest within the first day, and improvements were retained at subsequent test sessions. The pace of learning was faster for stimuli produced by native speakers of English as compared to non-native English speakers.

Assessment methods for determining small changes in hearing performance over time.

Although the behavioral pure-tone threshold audiogram is considered the gold standard for quantifying hearing loss, assessment of speech understanding, especially in noise, is more relevant to quality of life but is only partly related to the audiogram. Metrics of speech understanding in noise are therefore an attractive target for assessing hearing over time. However, speech-in-noise assessments have more potential sources of variability than pure-tone threshold measures, making it a challenge to obtain results reliable enough to detect small changes in performance. This review examines the benefits and limitations of speech-understanding metrics and their application to longitudinal hearing assessment, and identifies potential sources of variability, including learning effects, differences in item difficulty, and between- and within-individual variations in effort and motivation. We conclude by recommending the integration of non-speech auditory tests, which provide information about aspects of auditory health that have reduced variability and fewer central influences than speech tests, in parallel with the traditional audiogram and speech-based assessments.

Examining the context benefit in older adults: A combined behavioral-electrophysiologic word identification study.

When listening to degraded speech, listeners can use high-level semantic information to support recognition. The literature contains conflicting findings regarding older listeners' ability to benefit from semantic cues in recognizing speech, relative to younger listeners. Electrophysiologic (EEG) measures of lexical access (N400) often show that semantic context does not facilitate lexical access in older listeners; in contrast, auditory behavioral studies indicate that semantic context improves speech recognition in older listeners as much as or more than in younger listeners. Many behavioral studies of aging and the context benefit have employed signal degradation or alteration, whereas this stimulus manipulation has been absent in the EEG literature, a possible reason for the inconsistencies between studies. Here we compared the context benefit as a function of age and signal type, using EEG combined with behavioral measures. Non-native accent, a common form of signal alteration which many older adults report as a challenge in daily speech recognition, was utilized for testing. The stimuli included English sentences produced by native speakers of English and Spanish, containing target words differing in cloze probability. Listeners performed a word identification task while 32-channel cortical responses were recorded. Results show that older adults' word identification performance was poorer in the low-predictability and non-native talker conditions than the younger adults', replicating earlier behavioral findings. However, older adults did not show reduction or delay in the average N400 response as compared to younger listeners, suggesting no age-related reduction in predictive processing capability. Potential sources for discrepancies in the prior literature are discussed.

Semantic context and stimulus variability independently affect rapid adaptation to non-native English speech in young adults.

When speech is degraded or challenging to recognize, young adult listeners with normal hearing are able to quickly adapt, improving their recognition of the speech over a short period of time. This rapid adaptation is robust, but the factors influencing rate, magnitude, and generalization of improvement have not been fully described. Two factors of interest are lexico-semantic information and talker and accent variability; lexico-semantic information promotes perceptual learning for acoustically ambiguous speech, while talker and accent variability are beneficial for generalization of learning. In the present study, rate and magnitude of adaptation were measured for speech varying in level of semantic context, and in the type and number of talkers. Generalization of learning to an unfamiliar talker was also assessed. Results indicate that rate of rapid adaptation was slowed for semantically anomalous sentences, as compared to semantically intact or topic-grouped sentences; however, generalization was seen in the anomalous conditions. Magnitude of adaptation was greater for non-native as compared to native talker conditions, with no difference between single and multiple non-native talker conditions. These findings indicate that the previously documented benefit of lexical information in supporting rapid adaptation is not enhanced by the addition of supra-sentence context.

Younger and older adults show non-linear, stimulus-dependent performance during early stages of auditory training for non-native English.

Older adults often report difficulty understanding speech produced by non-native talkers. These listeners can achieve rapid adaptation to non-native speech, but few studies have assessed auditory training protocols to improve non-native speech recognition in older adults. In this study, a word-level training paradigm was employed, targeting improved recognition of Spanish-accented English. Younger and older adults were trained on Spanish-accented monosyllabic word pairs containing four phonemic contrasts (initial s/z, initial f/v, final b/p, final d/t) produced in English by multiple male native Spanish speakers. Listeners completed pre-testing, training, and post-testing over two sessions. Statistical methods, such as growth curve modeling and generalized additive mixed models, were employed to describe the patterns of rapid adaptation and how they varied between listener groups and phonemic contrasts. While the training protocol failed to elicit post-test improvements for recognition of Spanish-accented speech, examination of listeners' performance during the pre-testing period showed patterns of rapid adaptation that differed, depending on the nature of the phonemes to be learned and the listener group. Normal-hearing younger and older adults showed a faster rate of adaptation for non-native stimuli that were more nativelike in their productions, while older adults with hearing impairment did not realize this benefit.

Peripheral deficits and phase-locking declines in aging adults.

Age-related difficulties in speech understanding may arise from a decrease in the neural representation of speech sounds. A loss of outer hair cells or decrease in auditory nerve fibers may lead to a loss of temporal precision that can affect speech clarity. This study's purpose was to evaluate the peripheral contributors to phase-locking strength, a measure of temporal precision, in recordings to a sustained vowel in 30 younger and 30 older listeners with normal to near normal audiometric thresholds. Thresholds were obtained for pure tones and distortion-product otoacoustic emissions (DPOAEs). Auditory brainstem responses (ABRs) were recorded in quiet and in three levels of continuous white noise (+30, +20, and +10 dB SNR). Absolute amplitudes and latencies of Wave I in quiet and of Wave V across presentation conditions, in addition to the slope of Wave V amplitude and latency changes in noise, were calculated from these recordings. Frequency-following responses (FFRs) were recorded to synthesized /ba/ syllables of two durations, 170 and 260 ms, to determine whether age-related phase-locking deficits are more pronounced for stimuli that are sustained for longer durations. Phase locking was calculated for the early and late regions of the steady-state vowel for both syllables. Group differences were found for nearly every measure except for the slopes of Wave V latency and amplitude changes in noise. We found that outer hair cell function (DPOAEs) contributed to the variance in phase locking. However, the ABR and FFR differences were present after covarying for DPOAEs, suggesting the existence of temporal processing deficits in older listeners that are somewhat independent of outer hair cell function.

Improving older adults' understanding of challenging speech: Auditory training, rapid adaptation and perceptual learning.

The literature surrounding auditory perceptual learning and auditory training for challenging speech signals in older adult listeners is highly varied, in terms of both study methodology and reported outcomes. In this review, we discuss some of the pertinent features of listener, stimulus, and training protocol. Literature regarding the elicitation of auditory perceptual learning for time-compressed speech, non-native speech, and noise-vocoded speech is reviewed, as are auditory training protocols designed to improve speech-in-noise recognition. The literature is synthesized to establish some over-arching findings for the aging population, including an intact capacity for auditory perceptual learning, but a limited transfer of learning to untrained stimuli.

Stability of Early Auditory Evoked Potential Components Over Extended Test-Retest Intervals in Young Adults.

OBJECTIVES: Synaptic damage from noise exposures can occur even in the absence of changes in hearing sensitivity in animal models. There is an unmet clinical need for measurements sensitive to such damage to the human auditory system that can augment the pure-tone audiogram. Early components (i.e., <10 msec) of the auditory evoked potential (AEP) may be useful noninvasive indicators of synaptic integrity. Wave I is a measure of synchronous neural activity at the level of the synapse between cochlear inner hair cells and the auditory nerve and may be of particular clinical utility. This amplitude measure has historically been classified as too variable in humans to be used for clinical waveform interpretation, though several recent reliability studies have challenged this view. The focus of the present study is to examine across-session stability of early AEP amplitude measures. DESIGN: In this study, amplitudes of early components (wave I, wave V, summating potential [SP]) of the AEP were measured in a cohort of 38 young adults aged 19 to 33 years (21 female). Stability of these amplitude measures was examined in a subset of 12 young adults (8 female), at time intervals ranging from 15 hr to 328 days between tests. Eligibility criteria included normal pure-tone hearing sensitivity, normal tympanometry, and intact acoustic reflexes. Participants were tested at up to four time points. Each evaluation included pure-tone thresholds, tympanometry, speech-in-noise testing, distortion-product otoacoustic emissions (DPOAE), and early AEPs. AEPs were collected in response to click and tone burst stimuli, with both ear canal and mastoid electrode montages. RESULTS: No clinical changes in pure-tone hearing were found between baseline and follow-up visits. Intraclass correlation coefficients (ICCs) indicated good to excellent reliability for wave I and wave V peak-to-trough amplitudes within individuals across time, with greatest reliability (0.92, 95% confidence interval [0.81 to 0.96]) and largest amplitudes for wave I when measured from the ear canal in response to a click stimulus. Other measures such as amplitude ratios of waves V/I and the SP and action potential (AP) showed lower ICC values when measured from the ear canal, with SP/AP ratio demonstrating the lowest reliability. CONCLUSIONS: The results of this study suggest that, when recorded under certain conditions, wave I amplitude can be a stable measure in humans. These findings are consistent with previous work and may inform the development of clinical protocols that utilize wave I amplitude to infer inner ear integrity.

Effects of Listener Age and Native Language Experience on Recognition of Accented and Unaccented English Words.

Purpose Older native speakers of English have difficulty in understanding Spanish-accented English compared to younger native English speakers. However, it is unclear if this age effect would be observed among native speakers of Spanish. The current study investigates the effects of age and native language experience with Spanish on the ability to recognize words spoken in English by Spanish-accented and unaccented talkers. Method English monosyllabic words, recorded by native speakers of English and Spanish, were presented to 4 groups of listeners with normal hearing: younger native Spanish listeners ( n = 15), older native Spanish listeners ( n = 16), younger native English listeners ( n = 15), and older native English listeners ( n = 15). Speech recognition accuracy was assessed for the unaccented and accented words in both quiet and noise. Results In all conditions, the native English listeners performed better than the native Spanish listeners. More specifically, the native speakers of Spanish consistently recognized accented English less accurately than the native speakers of English, demonstrating no advantage of shared native language experience between nonnative listeners and accented talkers. Older listeners in the native Spanish language group also performed less accurately than their younger counterparts, for English words spoken by both unaccented and accented talkers. Finally, whereas listeners who were native speakers of English showed marked declines in recognition of Spanish-accented English relative to unaccented English, listeners who were native speakers of Spanish (both younger and older) showed less decline. Conclusions The general pattern of results suggests that both native language experience in a language other than English and age limit the ability to recognize Spanish-accented English. The implication of the overall findings is that older nonnative listeners will have considerable difficulty in understanding English, regardless of the talker's accent, in both clinical and everyday listening situations.

All-night functional magnetic resonance imaging sleep studies.

BACKGROUND: Previous functional magnetic resonance imaging (fMRI) sleep studies have been hampered by the difficulty of obtaining extended amounts of sleep in the sleep-adverse environment of the scanner and often have resorted to manipulations such as sleep depriving subjects before scanning. These manipulations limit the generalizability of the results. NEW METHOD: The current study is a methodological validation of procedures aimed at obtaining all-night fMRI data in sleeping subjects with minimal exposure to experimentally induced sleep deprivation. Specifically, subjects slept in the scanner on two consecutive nights, allowing the first night to serve as an adaptation night. RESULTS/COMPARISON WITH EXISTING METHOD(S): Sleep scoring results from simultaneously acquired electroencephalography data on Night 2 indicate that subjects (n = 12) reached the full spectrum of sleep stages including slow-wave (M = 52.1 min, SD = 26.5 min) and rapid eye movement (REM, M = 45.2 min, SD = 27.9 min) sleep and exhibited a mean of 2.1 (SD = 1.1) nonREM-REM sleep cycles. CONCLUSIONS: It was found that by diligently applying fundamental principles and methodologies of sleep and neuroimaging science, performing all-night fMRI sleep studies is feasible. However, because the two nights of the study were performed consecutively, some sleep deprivation from Night 1 as a cause of the Night 2 results is likely, so consideration should be given to replicating the current study with a washout period. It is envisioned that other laboratories can adopt the core features of this protocol to obtain similar results.

Effects of listener age and native language on perception of accented and unaccented sentences.

Degradations to auditory input have deleterious effects on speech recognition performance, especially by older listeners. Alterations to timing information in speech, such as occurs in rapid or foreign-accented speech, can be particularly difficult for older people to resolve. It is currently unclear how prior language experience modulates performance with temporally altered sentence-length speech utterances. The principal hypothesis is that prior experience with a foreign language affords an advantage for recognition of accented English when the talker and listener share the same native language, which may minimize age-related differences in performance with temporally altered speech. A secondary hypothesis is that native language experience with a syllable-timed language (Spanish) is advantageous for recognizing rapid English speech. Native speakers of English and Spanish completed speech recognition tasks with both accented and unaccented English sentences presented in various degrees of time compression (TC). Native English listeners showed higher or equivalent recognition of accented and unaccented English speech compared to native Spanish listeners in all TC conditions. Additionally, significant effects of aging were seen for native Spanish listeners on all tasks. Overall, the results did not support the hypotheses for a benefit of shared language experience for non-native speakers of English, particularly older native Spanish listeners.

Adaptation to novel foreign-accented speech and retention of benefit following training: Influence of aging and hearing loss.

Adaptation to speech with a foreign accent is possible through prior exposure to talkers with that same accent. For young listeners with normal hearing, short term, accent-independent adaptation to a novel foreign accent is also facilitated through exposure training with multiple foreign accents. In the present study, accent-independent adaptation is examined in younger and older listeners with normal hearing and older listeners with hearing loss. Retention of training benefit is additionally explored. Stimuli for testing and training were HINT sentences recorded by talkers with nine distinctly different accents. Following two training sessions, all listener groups showed a similar increase in speech perception for a novel foreign accent. While no group retained this benefit at one week post-training, results of a secondary reaction time task revealed a decrease in reaction time following training, suggesting reduced listening effort. Examination of listeners' cognitive skills reveals a positive relationship between working memory and speech recognition ability. The present findings indicate that, while this no-feedback training paradigm for foreign-accented English is successful in promoting short term adaptation for listeners, this paradigm is not sufficient in facilitation of perceptual learning with lasting benefits for younger or older listeners.

An independent construct for conditional expression of atonal homolog-1.

The mammalian homolog of the basic helix-loop-helix transcription factor atonal-1 (Atoh1 or Math1) is required for development of cochlear hair cells that function as the mechanosensory cells required for audition. Forced expression of Atoh1 in cochlear-supporting cells may provide a way to regenerate hair cells and provide for a therapy for hearing loss. Additionally, Atoh1 is an inhibitor of proliferation and has further clinical applications in anticancer therapies. The goal of these experiments was to improve the method for Atoh1 expression by engineering a genetic construct that may be used in future translational applications. To address the poor control of Atoh1 expression in standard gene expression systems where Atoh1 is expressed constitutively at abnormally elevated levels, our aim was to engineer an inducible system whereby Atoh1 was upregulated by an inducer and downregulated once the inducer was removed. A further aim was to engineer a single genetic construct that allowed for conditional expression of Atoh1 independent of secondary regulatory elements. Here we describe a stand-alone genetic construct that utilizes the tamoxifen sensitivity of a mutated estrogen receptor (ER) ligand-binding domain for the conditional expression of Atoh1. The Atoh1-ER-DsRed construct is translated into an ATOH1-ER-DSRED fusion protein that remains sequestered in the cytoplasm and therefore rendered inactive because it cannot enter the nucleus to activate Atoh1 signaling pathways. However, application of 4-hydroxytamoxifen results in translocation of the fusion protein to the nucleus, where it binds to the Atoh1 enhancer, upregulates transcription and translation of endogenous ATOH1 and activates downstream Atoh1 signaling such as upregulation of the hair cell protein MYOSIN 7A. Removal of tamoxifen reverses the upregulation of endogenous Atoh1 signaling. This construct serves as an independent genetic construct that allows for the conditional upregulation and downregulation of Atoh1, and may prove useful for manipulating Atoh1 expression in vivo.

TAK1 expression in the cochlea: a specific marker for adult supporting cells.

Transforming growth factor-ß-activated kinase-1 (TAK1) is a mitogen activated protein kinase kinase kinase that is involved in diverse biological roles across species. Functioning downstream of TGF-ß and BMP signaling, TAK1 mediates the activation of the c-Jun N-terminal kinase signaling pathway, serves as the target of pro-inflammatory cytokines, such as TNF-α, mediates NF-κß activation, and plays a role in Wnt/Fz signaling in mesenchymal stem cells. Expression of TAK1 in the cochlea has not been defined. Data mining of previously published murine cochlear gene expression databases indicated that TAK1, along with TAK1 interacting proteins 1 (TAB1), and 2 (TAB2), is expressed in the developing and adult cochlea. The expression of TAK1 in the developing cochlea was confirmed using RT-PCR and immunohistochemistry. Immunolabeling of TAK1 in embryonic, neonatal, and mature cochleas via DAB chromogenic and fluorescent immunohistochemistry indicated that TAK1 is broadly expressed in both the developing otocyst and periotic mesenchyme at E12.5 but becomes more restricted to specific types of supporting cells as the organ of Corti matures. By P1, TAK1 immunolabeling is found in cells of the stria vascularis, hair cells, supporting cells, and Kölliker's organ. By P16, TAK1 labeling is limited to cochlear supporting cells. In the adult cochlea, TAK1 immunostaining is only present in the cytoplasm of Deiters' cells, pillar cells, inner phalangeal cells, and inner border cells, with no expression in any other cochlear cell types. While the role of TAK1 in the inner ear is unclear, TAK1 expression may be used as a novel marker for specific sub-populations of supporting cells.