ABSTRACT
OBJECTIVES: To assess clinical indication-specific antibiotic prescribing in pediatric practice in China based on the World Health Organization (WHO) Access, Watch, and Reserve (AWaRe) metrics and to detect potential problem areas. STUDY DESIGN: Pediatric prescription records on the 16th of each month during 2018 were sampled for all encounters at outpatient and emergency departments of 16 tertiary care hospitals via hospital information systems. Antibiotic prescribing patterns were analyzed across and within diagnostic conditions according to WHO AWaRe metrics and Anatomical Therapeutic Chemical (ATC) classification. RESULTS: A total of 260â001 pediatric encounters were assessed, and antibiotics were prescribed in 94â453 (36.3%). In 35â167 encounters (37.2%), at least 1 intravenous antibiotic was administered. WHO Watch group antibiotics accounted for 82.2% (n = 84â176) of all antibiotic therapies. Azithromycin (n = 15â791; 15.4%) was the most commonly prescribed antibiotic, and third-generation cephalosporins (n = 44â387; 43.3%) were the most commonly prescribed antibiotic class. In at least 66â098 encounters (70.0%), antibiotics were prescribed for respiratory tract conditions, mainly for bronchitis/bronchiolitis (n = 25â815; 27.3%), upper respiratory tract infection (n = 25â184; 26.7%), and pneumonia (n = 13â392; 14.2%). CONCLUSIONS: Overuse and misuse of WHO Watch group antibiotics for respiratory tract conditions and viral infectious diseases is common in pediatric outpatients in China. Pediatric antimicrobial stewardship should be strengthened using WHO AWaRe metrics.
