[Thyroxine (T4) levels in workers exposed to lead]. / Stezenie tyroksyny (T4) u ludzi pracujacych w stycznosci z olowiem.

Thirty men occupationally exposed to lead have been examined. The selection of subjects was based on increased lead poisoning indices as well as on the data proving there had been no thyroid disease incidence noted prior to the lead poisoning. Each of the subjects underwent determination of T4 concentration simultaneously with the measurement of three basic indicators of lead poisoning: ALA in urine and ZPP and Pb in blood. Three T4 concentration ranges have been obtained therefore all the cases have been divided into three groups: I increased T4 concentration: II normal T4 concentration; III decreased T4 concentration. In each group T4 concentrations have been compared with the poisoning indicators. The highest poisoning indicators have been found in group II exhibiting normal T4 concentrations (43.33% of cases). It differed significantly from group III (50.0% of cases) exhibiting decreased T4 concentrations. The determination values in group I (increased T4 concentrations) have been excluded from statistical calculations, as there were too few cases (6.67%). The discrepancy of T4 results, their pathological picture at lower values of poisoning indices evidence that the establishment of Pb effects upon thyroid function would call for the determination of a number of additional factors possibly affecting the mechanism handling this phenomenon.

Bioavailability of trithiozine (TR) in man and its relation to gastric secretion and gastrin plasma level.

Pharmacokinetics and gastric secretion suppressing properties of a new drug, trithiozine (TR), were studied in man. Its availability, if taken orally, is prompt and very good; its blood plasma level lasts for over 5 hr. In basal conditions volume of gastric juice is suppressed by TR as it is by propantheline bromide (PPB). In contradistinction to PPB, TR reduces basal acid output. After histamine stimulation TR is not as effective as PPB in reducing both volume and acid output. TR did not appear to affect the plasma gastrin level. Lack of typical anticholinergic side-effects such as dryness in mouth, vision blurring, etc., on the one hand, and antisecretory activity limited to basal conditions on the other, seem to offer a new modification of the old approach to therapy of gastroduodenal ulcer. Clinical trials seem justified.

[Health conditions of workers exposed to CS-2 in xanthate plants]. / Badania nad stanem zdrowia zalogi wytwórni ksantogenianów narazonej na dzialanie CS2.

26 men, aged 22-57, with various length of employment in xanthate plant, where they have been exposed to CS2, were subjected to laboratory examinations aiming to find out the effects of this substance on their health state. These studies had been produced by measurements of CS2 concentration in the air of work-posts, lasting for 7 months. This allowed to evaluate the exposure of the subjects and to compare the concentrations with the MAC, actually valid. The obtained results, both in the subjects blood and urine, did not unequivocally indicate any noxious effects of CS2, despite the fact that MAC in the air of working rooms was twice surpassed.