ABSTRACT
UNLABELLED: The aim of the study was the evaluation of number and morphologic parameters of blood platelets and sodium-proton platelet exchangers in pregnant women in the 3rd trimester of pregnancy, healthy (155) and with preeclampsia (40). RESULTS: Blood platelet number was significantly lower in patients with preeclampsia than in healthy subjects (195,000 vs 222,000). Mean platelet volume was significantly higher in patients with preeclampsia (9.5 fl vs 8.6 fl). The activity of Na+/H+ was slightly higher in pregnants with preeclampsia.
Subject(s)
Blood Platelets/cytology , Pre-Eclampsia/blood , Pregnancy/metabolism , Sodium-Hydrogen Exchangers/metabolism , Adult , Blood Platelets/metabolism , Blood Platelets/pathology , Case-Control Studies , Female , Humans , Hypertension/blood , Infant, Newborn , Predictive Value of Tests , Pregnancy/blood , Pregnancy Complications, Cardiovascular/blood , Pregnancy Trimester, Third , Risk Factors , Statistics, NonparametricABSTRACT
Synthesis of nitric oxide proceeds in the human myometrium. Decrease of its concentrations can play an essential part in the initiation of uterine contractions in term. Authors suppose, that inhibition of the synthesis of nitric oxide plays a role in premature labour. Concentrations of nitric oxide in women with threatening premature labour were marked. Group I consisted of women with premature departure of amniotic fluid, group II--woman with retained amniotic fluid and with idiopathic contractile activity, group III--woman with departure of amniotic fluid and with idiopathic contractile activity. Concentration of nitric oxide was lower in the group of women with a premature contractile activity in comparison with healthy pregnant women in the same period of pregnancy. Higher concentrations of nitric oxide were observed in the group of patients without contractile activity after departure of amniotic fluid.
Subject(s)
Amniotic Fluid/metabolism , Fetal Membranes, Premature Rupture/metabolism , Nitric Oxide/metabolism , Obstetric Labor, Premature/metabolism , Uterine Contraction/metabolism , Adult , Analysis of Variance , Case-Control Studies , Female , Fetal Membranes, Premature Rupture/blood , Humans , Myometrium/metabolism , Nitric Oxide/blood , Obstetric Labor, Premature/blood , Obstetric Labor, Premature/prevention & control , Pregnancy , Pregnancy Trimester, Third , Risk Factors , Time FactorsABSTRACT
The aim of the study was to determine the concentrations of TGF-beta, PDGF and VEGF growth factors in peripheral blood. The examinations were carried out in the group of pregnant women with preeclampsia. The results were compared to those obtained in a control group of healthy pregnant women. The statistically significant increase in all examined growth factors was observed in women with preeclampsia in comparison to healthy women. The results suggest that growth factors may play an important role in etiology and pathophysiology of preeclampsia.
