Basal cell carcinoma and rosacea: coincidence or relationship?

Introduction: The relationship between rosacea and basal cell carcinoma (BCC) is still not known. Almost all reports questioning the relation between BCC and rosacea are focused on rhinophyma. Aim: To examine the possible connection of BCC and rosacea. Material and methods: 110 patients with BCC located on the face treated surgically in the Dermatosurgery Unit in 2020-2021 were included in the study. A trained dermatologist assessed the presence or absence of concomitant rosacea and assessed its severity according to the Investigator's Global Assessment (IGA). Results: Fifty-one (46.4%) subjects with BCC and concomitant clinically diagnosed rosacea were found. In our group 35.5% of women had BCC located on the cheeks, while in men most cancers were located on the nose (55%, n = 11), however this difference has not reached statistical significance. Conclusions: The incidence of rosacea in our population was undoubtedly higher, comparing to the normative population. Both rosacea and BCC share the same risk factors - UV exposure, the potential association should not be neglected.

Diagnosis of the Pneumatic Wheel Condition Based on Vibration Analysis of the Sprung Mass in the Vehicle Self-Diagnostics System.

This paper presents a method for the multi-criteria classification of data in terms of identifying pneumatic wheel imbalance on the basis of vehicle body vibrations in normal operation conditions. The paper uses an expert system based on search graphs that apply source features of objects and distances from points in the space of classified objects (the metric used). Rules generated for data obtained from tests performed under stationary and road conditions using a chassis dynamometer were used to develop the expert system. The recorded linear acceleration signals of the vehicle body were analyzed in the frequency domain for which the power spectral density was determined. The power field values for selected harmonics of the spectrum consistent with the angular velocity of the wheel were adopted for further analysis. In the developed expert system, the Kamada-Kawai model was used to arrange the nodes of the decision tree graph. Based on the developed database containing learning and testing data for each vehicle speed and wheel balance condition, the probability of the wheel imbalance condition was determined. As a result of the analysis, it was determined that the highest probability of identifying wheel imbalance equal to almost 100% was obtained in the vehicle speed range of 50 km/h to 70 km/h. This is known as the pre-resonance range in relation to the eigenfrequency of the wheel vibrations. As the vehicle speed increases, the accuracy of the data classification for identifying wheel imbalance in relation to the learning data decreases to 50% for the speed of 90 km/h.

Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas.

BACKGROUND: Patients with diagnosed keratinocyte carcinomas (KCs) have an increased risk of subsequent skin cancers development. Current studies indicate that patients with subsequent tumors should be followed up regularly. However, none of the studies indicate the connection between the specific subtypes and an increased risk for further KCs development. The study assesses the differences in the risk of developing a subsequent skin cancer after a previous diagnosis of KC, especially considering individual types of skin malignances, and identifies potential factors associated with an increased risk of new cutaneous tumor describing non-invasive diagnosis and monitoring. METHODS: Pathology and medical records were examined to identify the characteristics of patients with multiple KCs diagnosed between 1999 and 2019. RESULTS: The study group comprised 13,913 KCs occurring in 10,083 patients. Multiple KCs were observed in 2300 patients (22.8%). The analysis showed aggressive subtypes, multiple tumors, and male sex as significant prognostic factors. CONCLUSIONS: The most crucial risk factors for developing subsequent KC are being of a male gender, an aggressive tumor subtype, and previous history of multiple skin cancers. Basal cell carcinoma subtypes, such as infiltrative basosquamous, with aggressive growth patterns predispose not only to increased risk for the recurrence but are also expected to be at higher risk of subsequent KCs.

Basal cell carcinoma within rhinophyma: coincidence or relationship?

INTRODUCTION: Rhinophyma is a relatively rare form of rosacea, while basal cell carcinoma (BCC) is the most frequent skin cancer in humans - both diseases prevail in the elderly. AIM: To analyse patients with rhinophyma treated surgically in the Dermatosurgery Unit and look for possible cases with BCC within the rhinophyma. MATERIAL AND METHODS: We performed a retrospective review of all treated rhinophymas in the Dermatosurgery Unit in 2004-2019. RESULTS: Among 140 rhinophyma patients 2 (1.4%) subjects with concomitant clinically diagnosed and histologically confirmed BCC were found, with BCC located in the hypertrophic tissue of the nose. There were no patients with BCC located in other anatomical regions of the skin. Both of these patients were in more advanced age. CONCLUSIONS: Taking into consideration these two conditions: advanced age and anatomical location, typical for BCC, one may speculate that the development of BCC within rhinophyma is rather a simple coincidence. However, more numerous series of patients with rhinophyma are needed to clear the controversy of BCC within rhinophyma hypertrophic tissue.

The Use of Multicriteria Inference Method to Identify and Classify Selected Combustion Engine Malfunctions Based on Vehicle Structure Vibrations.

Internal combustion engines are among the most commonly used propulsion units for drive systems in various industries such as land transportation, maritime transportation, and power generation. Their operation involves a continuous change of technical condition as a result of not only the combustion process but also their operation under conditions of variable load or ambient impact. It is therefore important to monitor the technical condition of internal combustion engines to ensure high performance and reliability over their lifetime. The article presents the test results obtained from incorrect operation of an internal combustion engine as a result of forced failures of the ignition and injection system. On this basis, a multicriteria comparison of the signal analysis of engine block vibrations was made, after the transformation of the signal from the time domain to the frequency domain, by using the induction technique obtained from the operation of decision tree algorithms. For this purpose, the amplitude spectrum in the frequency domain, scaled to absolute values of discretization for which teaching and testing data tables were created for successive harmonics, was determined for the engine block vibration signal being tested. On the basis of the developed algorithm using decision trees, a multicriteria data table was analyzed for which a compatibility path for the analyzed engine block vibration signal is created. In this way, it is confirmed with a specified degree of effectiveness, depending on the point of operation of the engine resulting from its crankshaft speed, that there is a possibility of detecting a preset ignition or injection system malfunction in the technical condition of the internal combustion engine with a probability up to about 72%.

The incidence and clinical analysis of non-melanoma skin cancer.

Non-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is the most frequent skin cancer, followed by squamous cell carcinoma (SCC). Unfortunately, most European cancer registries do not record individual types of NMSC. To evaluate the incidence of primary BCCs and SCCs regarding age, sex, tumour site and tumour subtype to determine trends in epidemiology of both cancers. Retrospective analysis of BCCs and SCCs diagnosed and treated across seven sites in Poland from 1999 to 2019. We recorded 13,913 NMSCs occurring in 10,083 patients. BCC represented 85.2% of all cases. SCC patients were older than BCC patients (77.1 ± 11.3 years vs. 70.1 ± 12.3 years, p < 0.01). The nodular subtype was the most common subtype of BCC, followed by the superficial and infiltrative subtypes. The superficial BCC subtype was more common on photoprotected areas (p < 0.01), whereas the nodular BCC subtype occurred on the face (p < 0.01). The high-risk SCC subtypes were more common on face compared to low-risk SCC subtypes (p < 0.01). BCC and SCC are common malignancies developing at various ages and anatomical sites. These data underline the need for better registration policies regarding NMSC in order to improve prevention and treatment strategies for these tumours.

Serum Concentration and Skin Expression of S100A7 (Psoriasin) in Patients Suffering from Hidradenitis Suppurativa.

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. An important role of innate immune dysregulation in the pathogenesis of HS has been highlighted. S100A7 (psoriasin) is an innate, antimicrobial protein that exerts proinflammatory and chemotactic action. OBJECTIVES: The objective of the study was to investigate serum concentrations of S100A7 in individuals with HS as compared to healthy controls. Further, we evaluated the expression of S100A7 in lesional HS skin as compared to perilesional (clinically uninvolved) HS skin and normal skin. METHODS: Serum concentrations of S100A7 were evaluated with a commercially available ELISA kit. The expression of S100A7 in the skin was assessed using qRT-PCR and immunofluorescence staining. RESULTS: We found increased expression of S100A7 in lesional HS skin as compared to perilesional HS skin (p = 0.0017). The expression of S100A7 in lesional HS skin was positively associated with serum C-reactive protein concentration and the severity of disease according to Hurley staging. The serum concentration of S100A7 in individuals with HS was decreased as compared to healthy controls and patients with psoriasis. CONCLUSIONS: Upregulated in lesional HS skin, S100A7 may enhance the inflammatory process and contribute to the HS pathogenesis.

Clinical and epidemiological analysis of basosquamous carcinoma: results of the multicenter study.

Basosquamous carcinoma (BSC) is a rare non-melanoma skin cancer that shares the characteristic features of both basal and squamous cell carcinomas (BCC, SCC). Our research enables better characterization of BSC in comparison to high-risk subtypes of BCC and SCC. Paper includes a retrospective analysis of BSC cases regarding sex, age, number of tumors and anatomical distribution in comparison to BCC and SCC evaluating the differences and defining the implications. Histologically confirmed carcinomas recorded between 1999 and 2019 were studied. 181 diagnosed BSC cases were identified, making this study the largest cohorts of BSC patients reported worldwide. Most cases were reported on head and neck. Analysis of facial anatomic distribution shows that most commonly affected sites were the nose (43%) and the cheek (25%). The age at excision of metatypical BCC was higher than those of low-risk BCC (P < 0.05), however similar to high-risk BCC (P = 0.20). We revisited that the concept of BSC is the most similar to high-risk subtypes of BCC. Patients with diagnosed BSC have higher risk of second nonmelanoma skin cancer. Therefore, the frequency of follow-up examination should be adjusted to the individual risk of another skin cancer.

Assessment of gait stability and preferred walking speed in virtual reality.

PURPOSE: Analysis of human gait as well as diagnosis of human locomotion organ should always be conducted with velocity of gait equal to Preferred Walking Speed (PWS). The literature review shows that the PWS value is not the same in real and virtual environment. The aim of this study was to determine PWS values in both environments and to specify values of parameters used in equations enabling PWS calculations on the basis of lower limb length. METHODS: Research-related tests involved 40 subjects walking on the treadmill and wearing HMD goggles. The spatial scenery made participants feel like during a walk in the park. The tests included measurements of displacements of the COP, allowing for the calculation of the Lyapunov exponent and Floquet Multiplier. Both coefficients were used to identify stability at various gait velocities. RESULTS: The analysis revealed that the PWS in relation to gait on the treadmill with VR was lower than the PWS without VR. The final stage of research involved the determination of new values of coefficients of the formula enabling the identification of the velocity of comfort of gait in VR. CONCLUSIONS: Obtained results proved that PWS in real and virtual environment are different. The lower values were obtained for measurements in VR. On the basis of these results, value of the "a" coefficient, used in PWS calculations on the basis of lower limb length, was re-determined. The new value makes it possible to assess PWS for gait conducted on treadmill in virtual environment, what can be very important in gait evaluation.

The assessment of the kinematics of the rescuer in continuous chest compression during a 10-min simulation of cardiopulmonary resuscitation.

BACKGROUND: In pursuit of improvement in cardiopulmonary resuscitation (CPR), new technologies for the measurement and assessment of CPR quality are implemented. In our study, we assessed the kinematics of the rescuer during continuous chest compression (CCC-CPR). The proper performance of the procedure is a survival predictor for patients with cardiac arrest (CA). The purpose of the study was a prospective assessment of the kinematics of the rescuer's body with consideration given to the depth and rate of chest compression (CC) as the indicator of properly performed CC maneuver by professional and non-professional rescuers during a simulation of a 10-min CCC using a manikin. METHODS: Forty participants were enrolled in the study. CCC-CPR was performed in accordance with the 2015 AHA guidelines on a manikin positioned on the floor. Kinematic data on the movement were obtained from the measuring system (X-sens MVN Biomech) transmitting information from 17 inertial sensors. Measurement data were imported to the author's program RKO-Kinemat written in the Matlab and C # environments. Two groups of results were distinguished: Group I-results of CC with the depth of ≥ 40 mm and Group 2-CC results with the depth of < 40 mm. RESULTS: The multiple regression model demonstrated that the path length, left knee flexion angle, and left elbow flexion angle were the essential elements of the rescuer's kinematics that facilitated achieving and maintaining the normal depth of CC. CONCLUSIONS: We believe that raising the rescuer's hips by moving the center of the rescuer's body over the point of sternal compression increases the value of the CC force vector, thereby increasing the depth of CC. In addition, we observed that, during an effective CC, the rescuer was unable to maintain arms straight and, in consequence, a slight elbow flexion was observed. It, however, did not influence the quality of the maneuver.

Influence of changing frequency and various sceneries on stabilometric parameters and on the effect of adaptation in an immersive 3D virtual environment.

PURPOSE: The aim of the study was to examine the influence of different types of virtual sceneries and frequencies of movement of visual disturbances on stabilometric values as well as whether individual sceneries and changing frequency can minimize effect of adaptation of tested person to applied disturbances. METHODS: There were 23 healthy participants. A person has been standing on a Zebris stabilometric platform. Virtual 3D environment was displayed by means of HMD Oculus Rift system. An open (a meadow) and closed (a room) sceneries were used. The sceneries moved along the sagittal axis and rotated around horizontal axis. The measurement lasted 30 seconds and in the middle of it frequency of translational movement was changed from 0.7 Hz to 1.4 Hz or from 1.4 Hz to 0.7 Hz. RESULTS: The data were reported as medians of COP velocity and ellipse area. Visual disturbances caused the increase of these values in comparison with the tests conducted with open eyes. Results divided into periods (the first and the second 15 seconds) showed that in the first half of the test values were higher compared to the second half. The comparison of values obtained for open and closed scenery showed that higher values were recorded for open scenery. CONCLUSIONS: The comparison of both types of sceneries on the basis of COP velocity and ellipse area showed that open scenery had a greater impact on the measured stabilometric values. It was found out as well that people got accustomed to the applied disturbances, but this effect was lower in the open scenery.

The Upper Limb Motion Deviation Index: A new comprehensive index of upper limb motion pathology.

PURPOSE: The aim of the research was to formulate a new index enabling assessment of the overall pathology of the upper limb movement. It defines the difference between the pathological movement and a normal movement pattern. METHODS: Methodology of determining the index is based on a mathematical algorithm for calculating the Gait Deviation Index which is based on advanced methods of image comparison. To calculate the ULMDI index, one must divide the analyzed movement into cycles appropriate to the nature of the movement (similarly in gait it is the gait cycle) and then determine kinematic quantities (courses of joint angles). RESULTS: A group of 23 healthy people (10 women: k1-k10 and 13 men: m1-m13) as the reference group and a group of 3 persons with mobility impairments (p1-p3) took part in the research. Time values of the angles of the joints on both upper limbs were registered and then ULMDI indexes were calculated. CONCLUSIONS: It has been shown that the developed ULMDI index allows to detect the deviations from the accepted norm in the performance of movements. The results showed that both the description of the motor dysfunction of examined person based on the diagnosis of the physician, a detailed analysis of kinematic waveforms received during the tests and the calculated values provide a coherent picture of the state of a human movement. The index analysis is less time-consuming for the doctor, and the comparison of the results at various stages of therapy gives an objective picture of the rehabilitation progress.

Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents.

BACKGROUND: Biologics seem to offer a promising nonsurgical approach in hidradenitis suppurativa (HS), especially in disease with highly pronounced inflammation. Recent studies revealed increased expression of a broad range of cytokines in lesional HS skin, including interleukin (IL)-17. OBJECTIVE: This study was undertaken to determine IL-17 serum levels in this group of patients. METHODS: Our study was conducted on a group of 86 patients between 16 and 72 years of age with HS. A total of 86 matched healthy volunteers constituted the control group. Enzyme-linked immunosorbent assay kits were used to quantify IL-17 serum concentration. RESULTS: The mean IL-17 serum level of patients with HS was 3.68 ± 2.08 pg/mL, which was significantly elevated (P < .0001) compared with that found in healthy volunteers (2.5 ± 1.11 pg/mL). Moreover, there was a tendency toward higher serum concentrations of IL-17 in patients with more advanced disease (P = .005). Disease duration; patient sex, age, and body mass index; and smoking habits were not determining factors for IL-17 serum concentration. LIMITATIONS: Hospital-based study population was a limitation, as was a lack of posttreatment assessment. CONCLUSION: In light of our findings and literature on increased expression of IL-17 in HS lesions, evaluating the clinical effectiveness of using anti-IL-17 agents in the treatment of patients with HS is justified.

The Standard Deviation of Differential Index as an innovation diagnostic tool based on kinematic parameters for objective assessment of a upper limb motion pathology.

PURPOSE: Indexing methods are very popular in terms of determining the degree of disability associated with motor dysfunctions. Currently, indexing methods dedicated to the upper limbs are not very popular, probably due to difficulties in their interpretation. This work presents the calculation algorithm of new SDDI index and the attempt is made to determine the level of physical dysfunction along with description of its kind, based on the interpretation of the calculation results of SDDI and PULMI indices. METHODS: 23 healthy people (10 women and 13 men), which constituted a reference group, and a group of 3 people with mobility impairments participated in the tests. In order to examine possibilities of the utilization of the SDDI index the participants had to repetitively perform two selected rehabilitation movements of upper extremities. During the tests the kinematic value was registered using inertial motion analysis system MVN BIOMECH. RESULTS: The results of the test were collected in waveforms of 9 anatomical angles in 4 joints of upper extremities. Then, SDDI and PULMI indices were calculated for each person with mobility impairments. Next, the analysis was performed to check which abnormalities in upper extremity motion can influence the value of both indexes and interpretation of those indexes was shown. CONCLUSION: Joint analysis of the both indices provides information on whether the patient has correctly performed the set sequence of movement and enables the determination of possible irregularities in the performance of movement given.

The influence of frequency of visual disorders on stabilographic parameters.

PURPOSE: Defining the influence of parameters of visual disorders on ability of balancing turns out to be an important process in effective diagnostics. Current diagnostic methods relating mainly to determination of the coefficient of BRUTM (Balance Rehabilitation Unit Trade Mark) depend on lots of tests carried out in a disturbed environment created by Virtual Reality Technology. The aim of this study is to determine the effect of the frequency of visual disturbances on stabilographic values in the virtual reality environment. METHODS: The study was carried out involving one research group in Virtual Cave. There were induced visual disturbances with different frequencies and with the change of frequency during measuring the position of the center of pressure (COP) in the test. Before each test the reference test was performed. All tests were performed with disorders in two different sceneries: closed and open scenery. All measurements were carried out on an immobile Zebris platform which enables determination of feet pressure distribution. From the measured values of the position of the COP Short Time Fourier Transform (STFT) was calculated. RESULTS: The results of calculation are shown in graphs. Their analysis showed that changing the parameters of disorder frequency in world created using Virtual Reality Technology affects stabilographic parameters. The intensity of these changes is also affected by applied research scenery. CONCLUSIONS: Conditions have been set out to carry out similar studies in order to obtain reliable results. The study is the first step in a project to develop a system for diagnosis and rehabilitation of human movement using Virtual Reality Technology.