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2.
Hum Pathol ; 29(7): 683-8, 1998 Jul.
Article in English | MEDLINE | ID: mdl-9670824

ABSTRACT

This is a clinicopathologic review of 53 cases of primary synovial chondromatosis covering a period of 30 years. The average age at presentation was 41 years (range, 17 to 64 years) with a male/female preponderance of 1.8:1. The condition was always monarticular, the most common site being the knee joint (70%) followed by the hip (20%). Degenerative joint disease was well established in three patients (5%), all occurring in the hip. Nine patients suffered recurrences (15%), including three that became malignant. There was no relationship between the age and site of the lesion, nor between the degree of cellularity of the cartilage and age or site. However, there was an association between cellularity of the cartilage and the extent of calcification and ossification--highly cellular lesions were poorly calcified and ossified, but heavily calcified lesions were usually of relatively low cellularity. There was no relationship between extent of calcification and ossification and the age of the patient. Three patients suffered malignant change representing a relative risk of 5%, much higher than that quoted in other series. This suggests that primary synovial chondromatosis has a significant potential for malignant change.


Subject(s)
Bone Neoplasms/pathology , Cell Transformation, Neoplastic , Chondromatosis, Synovial/pathology , Precancerous Conditions/pathology , Adolescent , Adult , Aneuploidy , Bone Neoplasms/genetics , Chondromatosis, Synovial/diagnostic imaging , Chondromatosis, Synovial/surgery , Chondrosarcoma/genetics , Chondrosarcoma/pathology , Fatal Outcome , Female , Flow Cytometry , Humans , Joint Loose Bodies/diagnostic imaging , Joint Loose Bodies/pathology , Joint Loose Bodies/surgery , Knee Joint/diagnostic imaging , Knee Joint/pathology , Male , Middle Aged , Precancerous Conditions/diagnostic imaging , Precancerous Conditions/surgery , Radiography , Retrospective Studies
3.
Am J Surg Pathol ; 22(5): 615-9, 1998 May.
Article in English | MEDLINE | ID: mdl-9591732

ABSTRACT

Inhibin is a peptide hormone produced by ovarian granulosa cells and testicular Sertoli cells. Ovarian granulosa cell and other sex cord-stromal tumors usually exhibit positive immunohistochemical staining with antiinhibin antibodies, and this may be valuable in differentiating these neoplasms from histologic mimics. In the present study, we investigated the immunohistochemical staining of testicular sex cord-stromal tumors using antiinhibin. Immunostaining with CAM5.2, vimentin, S-100 protein, desmin, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) also was performed because few studies have investigated in detail the immunophenotype of testicular sex cord-stromal tumors. Fifteen of 16 Leydig cell tumors exhibited strong positive staining with antiinhibin. A proportion of Leydig cell tumors also stained positively with CAM5.2 (7 of 16), vimentin (14 of 16), S-100 protein (10 of 16), desmin (2 of 16) and epithelial membrane antigen (4 of 16). Four of six testicular sex cord-stromal tumors with varying degrees of Sertoli or granulosa cell differentiation were positive with antiinhibin, as were two of three sex cord-stromal tumors that were unclassified. Some of these tumors were positive with CAM 5.2, vimentin, S-100 protein, desmin, and epithelial membrane antigen. All tumors were negative with carcinoembryonic antigen and placental alkaline phosphatase. The immunohistochemical findings show that, analogous to their ovarian counterparts, most testicular sex cord-stromal tumors are immunoreactive with antiinhibin. Immunohistochemistry using this antibody as part of a panel may be valuable in confirming a diagnosis of testicular sex cord-stromal tumor and in differentiating these neoplasms from others that may mimic them.


Subject(s)
Inhibins/analysis , Sex Cord-Gonadal Stromal Tumors/chemistry , Testicular Neoplasms/chemistry , Antibodies, Monoclonal , Biomarkers, Tumor/analysis , Humans , Immunohistochemistry , Inhibins/immunology , Leydig Cell Tumor/chemistry , Male , Sertoli Cell Tumor/chemistry
7.
Br J Urol ; 71(5): 600-6, 1993 May.
Article in English | MEDLINE | ID: mdl-8518870

ABSTRACT

A total of 85 patients with paratesticular tumours were diagnosed over a period of 36 years at this hospital; 66 patients (78%) had benign tumours, usually either an adenomatoid tumour or a lipoma. Of the remaining 19 malignant cases, 10 were primary neoplasms and 9 were metastases. A rare mucin-secreting epididymal adenocarcinoma was the only primary malignant epithelial tumour, the others being of mesenchymal origin. In 4/9 metastatic cases the initial presentation of a paratesticular swelling led to the discovery of the occult primary neoplasm following histological examination. Clinical features of a painful or painless mass, with or without an accompanying hydrocele, do not help to distinguish a benign from a malignant lesion. The prognosis of malignant tumours of mesenchymal origin depends mainly on the histological grade. Surgical resection remains the mainstay of treatment and adjuvant therapy significantly improves the chances of survival only in young patients with paratesticular rhabdomyosarcomas. Older patients with high grade tumours usually succumb to their disease despite chemotherapy and/or radiotherapy.


Subject(s)
Genital Neoplasms, Male/pathology , Spermatic Cord/pathology , Adolescent , Adult , Aged , Child , Child, Preschool , Genital Neoplasms, Male/secondary , Genital Neoplasms, Male/therapy , Humans , Male , Middle Aged , Testicular Neoplasms/pathology , Testicular Neoplasms/secondary , Testicular Neoplasms/therapy , Testis/pathology , Treatment Outcome
9.
Br J Urol ; 71(1): 34-7, 1993 Jan.
Article in English | MEDLINE | ID: mdl-8435734

ABSTRACT

The majority of primary bladder neoplasms are known to arise within the mucosa around the ureteric orifices and bladder base. This may be due to the mucosa in this area being more susceptible to carcinogens than other areas of the bladder. Deficiency in the nucleotide salvage pathway enzyme thymidine kinase (TK), and especially its TK1 isozyme, has been shown to predispose cell lines to increased mutagenesis. Total TK and TK1 activities were measured in mucosal samples taken adjacent to the ureteric orifices and dome in 32 normal bladders and both total TK and TK1 were shown to be significantly decreased in the mucosa adjacent to the ureteric orifices. This may explain why primary bladder neoplasms occur more commonly in this site.


Subject(s)
Isoenzymes/analysis , Thymidine Kinase/analysis , Ureter/enzymology , Urinary Bladder Neoplasms/enzymology , Urinary Bladder/enzymology , Adult , Aged , Female , Humans , Male , Middle Aged , Mucous Membrane
11.
Q J Med ; 84(305): 713-8, 1992 Sep.
Article in English | MEDLINE | ID: mdl-1303650

ABSTRACT

Eighteen patients with a variety of non-gastrointestinal symptoms were incidentally found to have circulating antireticulin antibody and on subsequent testing were also positive for antigliadin antibody. They prospectively underwent jejunal biopsy to determine whether or not they had coeliac disease. Their age range was 21-79 years (mean 42 years). Enteropathy was present in 13 (72 per cent) and was always associated with circulating IgA antigliadin antibody. Enteropathy was not present in the five cases who had only IgG antibody. Clinical improvement occurred in eight of 11 patients who complied with a gluten-free diet and was paralleled by an improvement in the mucosal histology in seven of eight who were re-biopsied. The most remarkable cases were two patients who presented with severe debility and no apparent haematological or biochemical abnormalities, and who subsequently made a dramatic recovery on a gluten-free diet. It is concluded that antireticulin antibody detected by routine autoantibody screening and confirmed to have IgA antigliadin antibody specificity is a useful indicator of an otherwise undiagnosed enteropathy. This serves to emphasize that the condition can sometimes be associated with atypical features and significant morbidity.


Subject(s)
Antibodies/analysis , Autoantibodies/analysis , Celiac Disease/diagnosis , Gliadin/immunology , Immunoglobulin A/analysis , Reticulin/immunology , Adult , Aged , Celiac Disease/diet therapy , Celiac Disease/immunology , Celiac Disease/pathology , Female , Humans , Intestinal Mucosa/pathology , Jejunum/pathology , Male , Middle Aged
12.
J Clin Pathol ; 45(1): 16-20, 1992 Jan.
Article in English | MEDLINE | ID: mdl-1346789

ABSTRACT

AIMS: To assess c-erbB-2 immunostaining in relation to morphological type of in situ and invasive breast carcinoma. METHODS: Formalin fixed, wax embedded archival tissue was used. Invasive carcinomas comprised 50 infiltrating ductal (NOS); seven medullary, 10 tubular, 15 mucinous and 24 classic invasive lobular. In situ carcinomas comprised 48 ductal (DCIS) and 10 cases of lobular (LCIS). The antibodies used were pAB1 (polyclonal) which stains cell lines that over express the c-erbB-2 oncogene, and ICR 12 (monoclonal) which stains sections of breast carcinoma known to show c-erbB-2 amplification. RESULTS: Immunostaining consistent with c-erbB-2 overexpression was found in 10 out of 50 cases of infiltrating ductal carcinoma (NOS), one of 24 infiltrating lobular carcinomas and one of seven medullary carcinomas only. Seventy per cent of ICR 12 positive cases of infiltrating ductal carcinoma also had extratumoral DCIS. Forty six per cent of pure DCIS lesions also showed strong membrane staining for c-erbB-2 protein, confined to large cell types. CONCLUSIONS: Immunostaining for c-erb B-2 oncoprotein occurs mainly in large cell DCIS and infiltrating ductal carcinoma NOS, especially those with an extratumoral DCIS component. There is a low incidence in other types of breast cancer, including those associated with a better prognosis. Different biological mechanisms may be responsible for histologically distinct types of breast carcinoma.


Subject(s)
Breast Neoplasms/genetics , Breast Neoplasms/pathology , Gene Expression/physiology , Proto-Oncogene Proteins/chemistry , Proto-Oncogenes , Carcinoma in Situ/genetics , Carcinoma in Situ/pathology , Carcinoma, Intraductal, Noninfiltrating/genetics , Carcinoma, Intraductal, Noninfiltrating/pathology , Female , Humans , Neoplasm Invasiveness , Receptor, ErbB-2
13.
Gut ; 32(12): 1568, 1991 Dec.
Article in English | MEDLINE | ID: mdl-1773970

ABSTRACT

Lymphangiomas are rare tumours of lymphatic vessels, most commonly found in children. We present the unusual case of small bowel obstruction caused by benign lymphangioma in a middle aged woman.


Subject(s)
Intestinal Obstruction/etiology , Jejunal Diseases/etiology , Lymphangioma/complications , Peritoneal Neoplasms/complications , Female , Humans , Jejunal Diseases/pathology , Lymphangioma/pathology , Mesentery/pathology , Middle Aged , Peritoneal Neoplasms/pathology
15.
BMJ ; 303(6811): 1163-5, 1991 Nov 09.
Article in English | MEDLINE | ID: mdl-1747612

ABSTRACT

OBJECTIVE: To investigate the extent to which the detection of antibodies to gliadin, endomysium, and jejunum predicts the eventual diagnosis of coeliac disease according to the revised ESPGAN diagnostic criteria in a group of patients in whom there is a high suspicion of coeliac disease. DESIGN: Clinical assessment and laboratory analysis of patients with suspected coeliac disease. SETTING: Gastroenterology department of teaching hospital. PATIENTS: 96 adults with suspected coeliac disease attending for jejunal biopsy. MAIN OUTCOME MEASURES: Diagnosis of coeliac disease with the revised criteria of the European Society of Paediatric Gastroenterology and Nutrition in patients with and without antibodies associated with coeliac disease. RESULTS: 28 patients had a clinical diagnosis of coeliac disease, seven of other gastrointestinal diseases, and 12 of miscellaneous diseases; 49 had no diagnosis. Gliadin IgA detected by ELISA was found in all patients with coeliac disease and none of those without, giving a sensitivity, specificity, positive and negative predictive values, and predictive efficiency of 100% for diagnosing coeliac disease within the group. Endomysial IgA was found in 25 (89%) patients with coeliac disease and jejunal IgA in 21 (75%); neither IgA was found in patients without coeliac disease. CONCLUSION: Detection of gliadin IgA by ELISA and to a lesser extent the endomysial IgA should allow better selection of patients for jejunal biopsy and thus make diagnosing coeliac disease simpler and more efficient.


Subject(s)
Autoantibodies/analysis , Celiac Disease/diagnosis , Gliadin/immunology , Jejunum/immunology , Myofibrils/immunology , Adolescent , Adult , Aged , Aged, 80 and over , Celiac Disease/immunology , Female , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Male , Middle Aged , Predictive Value of Tests
17.
Histopathology ; 18(1): 67-71, 1991 Jan.
Article in English | MEDLINE | ID: mdl-1707395

ABSTRACT

The clinical, microscopical, immunocytochemical and ultrastructural features of five cases of benign mesenchymal proliferative lesions of the urinary bladder, mimicking sarcoma, are presented. Four of the five patients are alive and disease-free following diagnosis, an interval ranging from 9 months to 9 years, mean 4 years. A fifth patient, who had a pseudosarcomatous stromal response adjacent to a urinary transitional cell carcinoma, now has invasive transitional cell carcinoma. The lesions revealed a striking microscopical, immunocytochemical and ultrastructural similarity to nodular fasciitis, suggesting the lesions represented a bizarre mesenchymal proliferative response to inflammation.


Subject(s)
Carcinoma/pathology , Plant Lectins , Urinary Bladder Neoplasms/pathology , Adult , Carcinoma/metabolism , Carcinoma/ultrastructure , Desmin/metabolism , Female , Humans , Immunohistochemistry , Keratins/metabolism , Lectins , Male , Microscopy, Electron , Middle Aged , Urinary Bladder Neoplasms/metabolism , Urinary Bladder Neoplasms/ultrastructure , Vimentin/metabolism
18.
J Clin Pathol ; 43(7): 533-6, 1990 Jul.
Article in English | MEDLINE | ID: mdl-2380402

ABSTRACT

Between 1954 and 1988 only a total of twenty five cases of primary adenocarcinoma of the small bowel (excluding periampillary tumours) were recorded at the Department of Histopathology, Belfast City Hospital. Of these, 14 tumours were located in the jejunum: the remainder arose in the ileum. The average age at presentation was 61.3 years and a slight female to male preponderance of 1:7:1 was noted. The adenocarcinoma arose from a preexisting villous adenoma in six cases. The overall prognosis was poor, with a five year survival of 15.7%. All the survivors had tumours located in the jejunum. The single most important prognostic indicator was the depth of tumour invasion or stage at the time of diagnosis. Tumour size and grade did not seem to correlate well with survival. It is concluded that the rarity of these tumours and their inaccessibility hinder detection and treatment and that surgical resection is more effective than chemotherapy.


Subject(s)
Adenocarcinoma/pathology , Ileal Neoplasms/pathology , Jejunal Neoplasms/pathology , Adenocarcinoma/mortality , Adenocarcinoma/surgery , Adult , Aged , Aged, 80 and over , Female , Humans , Ileal Neoplasms/mortality , Ileal Neoplasms/surgery , Jejunal Neoplasms/mortality , Jejunal Neoplasms/surgery , Male , Middle Aged , Prognosis , Survival Rate
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