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Chronic myelogenous leukemia after lymphoid irradiation and heart transplantation.

Frist, W H; Biggs, V J.

Ann Thorac Surg ; 57(1): 214-6, 1994 Jan.

Article in English | MEDLINE | ID: mdl-8279896

ABSTRACT

We have previously reported a case of recurrent cardiac rejection in a heart transplant recipient successfully treated with total lymphoid irradiation. Five years after transplantation chronic myelogenous leukemia was diagnosed in this patient. The long-term effects of total lymphoid irradiation in the heart transplant population have not been reported. Based on the known relationships among irradiation, gene translocations, and leukemia, we postulate that this patient's chronic myelogenous leukemia may be a long-term sequela of previous total lymphoid irradiation.

Subject(s)

Graft Rejection/radiotherapy , Heart Transplantation , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/etiology , Leukemia, Radiation-Induced/etiology , Lymphatic Irradiation/adverse effects , Adult , Humans , Male

Successful treatment of invasive bronchial aspergillosis after single-lung transplantation.

Biggs, V J; Dummer, S; Holsinger, F C; Loyd, J E; Christman, B W; Frist, W H.

Clin Infect Dis ; 18(1): 123-4, 1994 Jan.

Article in English | MEDLINE | ID: mdl-8054428

Subject(s)

Aspergillosis/drug therapy , Lung Diseases, Fungal/drug therapy , Lung Transplantation , Postoperative Complications/drug therapy , Adult , Amphotericin B/therapeutic use , Drug Administration Schedule , Humans , Male

Transplantation for pulmonary hypertension.

Frist, W H; Carmichael, L C; Loyd, J E; Merrill, W H; Stewart, J R; Biggs, V J; Bender, H W.

Transplant Proc ; 25(1 Pt 2): 1159-61, 1993 Feb.

Article in English | MEDLINE | ID: mdl-8442071

Subject(s)

Hemodynamics , Hypertension, Pulmonary/surgery , Lung Transplantation/physiology , Adult , Blood Pressure , Cardiac Output , Child , Follow-Up Studies , Humans , Hypertension, Pulmonary/physiopathology , Lung Transplantation/methods , Middle Aged , Pulmonary Circulation , Stroke Volume , Vascular Resistance

ABSTRACT

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