ABSTRACT
Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
Subject(s)
Genetic Predisposition to Disease , Genetic Testing/methods , Genome, Human , Multiple Sclerosis/genetics , Adolescent , Adult , Alleles , Case-Control Studies , Female , Gene Frequency , Genetic Testing/statistics & numerical data , Humans , International Cooperation , Linkage Disequilibrium/genetics , Male , Microsatellite Repeats , Middle Aged , Multiple Sclerosis/epidemiology , Portugal/epidemiologyABSTRACT
A case of acute ischemia of the right inferior limb after anti-tuberculous therapy in a 42-Year old woman is reported. This complication was confirmed by artheriography and the investigation revealed vasculitis and anti-histone antibodies. Drug-induced lupus was then diagnosed. A brief review about this subject is also made.
