1.
Bioorg Med Chem Lett
; 21(21): 6567-72, 2011 Nov 01.
Article
in English
| MEDLINE
| ID: mdl-21920746
ABSTRACT
Pharmacophoric comparison between papaverine and tofisopam led to identify three new series of micro- to sub-micromolar inhibitors of phosphodiesterase-4, including 7,8-dialkoxy-2,3-benzodiazepin-4-one derivatives, 7,8-dialkoxy-1,4-benzodiazepin-2-one derivatives, and dialkoxybenzophenone derivatives.