[Myocardial reaction of the right ventricle to lung resection]. / Reaktsiia miokarda pravogo zheludochka serdtsa na rezektsii legkikh.

Right-sided pulmonectomy (resection of 63-65% of the lung parenchyma) in white noninbred rats resulted in development of chronic cor pulmonale, that develops according to the stages: I--from the time of the operation up to the 10th-15th days after the operation--the stage of acute disturbances and mobilization forces of the organism; II--from the 11th-15th up to the 90th day is the stage of a relative steady compensatory hypertrophy of the cardiac right ventricle; III--after the 90th day--the stage of decompensation. The hypertrophy of the right ventricle myocardium transfers into its dilatation. Amount of cardiomyocytes and their nuclei in 1 mg of the right ventricle tissue progressively decreases, quantity of multinuclear cardiomyocytes increases, ploidy of the nuclei changes: number of tetraploid nuclei decreases, octaploid nuclei appear. Lethality among the animals is 56%.

[Functional state of cells and intracellular structures exposed to regeneration stimulators at early stages of the membranotropic effect of environmental chemicals]. / Funktsional'noe sostoianie kletki i vnutrikletochnykh struktur pri vozdeistvii stimuliatorov regeneratsii na rannykh stadiiakh membranotropnogo éffekta khimicheskikh faktorov okruzhaiushchei sredy.

The authors provide the biochemical, morphological and morphometry data on the functions of the cells (alveolar macrophages of the lungs) and intracellular structures (lysosomes, microsomes) of the liver and macrophages from rats exposed to a widely spread carcinogen nitrosodimethylamine and to one of pyrimidine derivatives as a stimulant of regeneration processes. It has been demonstrated that the pyrimidine derivative may prevent the unfavourable metabolic effects occurring at the cellular level (alveolar macrophages of the lungs) and cell organelles (lysosomes and endoplasmic network) in the early stages of the membrane-damaging action of nitrosodimethylamine.

[Regulation of lung regeneration]. / Reguliatsiia regeneratsii legkikh.

The materials on lung regeneration are generalized, the prerequisites for the stimulation of compensatory hypertrophy of the lung tissue are considered, the results of application of regeneration stimulators in the experimental and clinical conditions are first systematized and analyzed. Experiments were carried on over 3,500 animals with the use of complex morphometrical, biochemical, autoradiographical, morphological, cytochemical methods; the functional state of lung tissue was evaluated under the conditions of application of regeneration stimulators. The application of purines and pyrimidines contributes to a more complete and rapid development of compensatory hypertrophy of the lung, restoration of the total alveolar surface, leads to the formation of alveoli de novo, prevents the appearance of the phenomena of morphological and functional decompensation at remote times after the operation, excludes the development of pneumofibrosis. The mechanisms of the stimulating effect of the drugs in question on the development of compensatory hypertrophy of the lung are revealed, a new classification is proposed.

The enzymatic status of circulating lymphocytes as an index of the regenerative process in the lungs under stimulation with pyrimidine and purine derivatives. A clinical experimental study.

Enzyme activities in the circulating lymphocytes permit to judge the character of the regenerative process in the lung, and the severity of the patient's condition; it helps in estimating the prognosis and in evaluating the efficacy of the applied therapy. Potassium orotate and Riboxin intensify the regenerative process in the lung undergoing a compensatory-hypertrophic rearrangement, and enhance the functional activity of circulating lymphocytes as participants of the regenerative process and stimulate the oxidation-reduction processes in lymphocytes.

[Enzymatic status of leukocytes in pyo-inflammatory diseases of the soft tissues and their changes caused by pyrimidine derivatives]. / Fermentnyi status leikotsitov pri gnoino-vospalitel'nykh zabolevaniiakh miagkikh tkanei i ego izmeneniia pod vliianiem pirimidinovykh proizvodnykh.

It has been established that data of cytochemical investigation of leukocytes can show the severity of the pathological process and contribute to prognosing further development of pyo-inflammatory disease. Pyrimidine derivatives have a pronounced normalizing effect on the enzyme activity of leukocytes.

[Age peculiarities in the content of nucleic acids, collagen (as oxyproline) and other proteins in rat skin and lung tissues]. / Vozrastnye osobennosti v soderzhanii nukleinovykh kislot, kollagena (po oksiprolinu) i drutikh belkov v tkaniakh kozhi i lerkikh krys.

It is established that in old animals, as compared to the young ones, the content of nucleic acids, the total content of protein and the content of the peptide-bound oxyproline in the collagen soluble fractions in the skin and lungs tissues decrease, whereas the content of peptide-bound oxyproline in the insoluble collagen and of free oxyproline, vice versa, increases.

[Effect of orotic acid on reparative processes in the lungs following pneumonectomy]. / Vliianie orotovoi kisloty na reparativnye protsessy v legkikh posle pnevmonéktomii.

The effect of orotic acid on pulmonary regeneration has been studied in mature rats after left-sided pneumonectomy. A complex morphometric analysis of the pulmonary parenchyma during the process of compensatory-hypertrophic rearrangement has been carried out; mitotic activity of cells in the interalveolar septae, peculiarities of DNA synthesis and those of enzymatic status in lymphocytes of the peripheral blood have been determined. As the investigations have demonstrated, the administration of orotic acid during the postoperative period contributes to a more complete regeneration of the lung volume, alveolar surface, results in formation of new alveoli, prevents the development of morphologic long-term decompensation following pneumonectomy. Activation of the alveolar cells proliferation and increased DNA synthesis are the main stimulating effects of orotic acid. Certain correlative connections are revealed between the course of pulmonary regenerative processes and the enzymic status of circulating lymphocytes.

[Effect of orotic acid on regeneration of the lungs]. / Vliianie orotovoi kisloty na regeneratsiiu legkikh.

The effect of orotic acid on the development of compensatory pulmonary hypertrophy has been studied in the clinic and in the experiments (71 patients, and 349 rats) carried out with the use of morphologic, biochemical cytochemical, immunologic and clinical methods, and also through autoradiography. The results of the study prove the effect of the drug upon the pulmonary regeneration. Experimental findings have shown that behind the stimulating effect of the drug there is the activation of the synthesis of nucleinic acids, the rise of the mitotic activity of the interalveolar membranes cells of the lung remnants. An essential increase of the lymphocytic dehydrogenase activity of the peripheral blood occurred in response to the effect of the drug.

[Effect of orotic acid on the regeneration processes after gastrectomy]. / Vliianie orotovoi kisloty na protsessy regeneratsii posle rezektsii zheludka.

Experiments on animals have shown a favourable effect of orotic acid upon reparative regeneration processes in injured abdominal wall and stomach. In the clinic the administration of orotic acid favoured the decrease of the incidence of postoperative complications from 32% to 14% and the acceleration of the wound healing by 30%.

[Effect of kanamycin on kidney function in children with suppurative, inflammatory diseases]. / Vliianie kanamitsina na funktsiiu pochek u detei s gnoino-vospalitel' nymi zabolevaniiami

The effect of kanamycin on the kidney function and the possibility of decreasing its side effect of pyrimidines were studied in240 children at the age of 2 month to 14 years (161 children with acute and chronic osteomyelitis and 79 children with staphylococcal destruction of the lungs). Kanamycin used in doses of 15000 and 25000 Units/kg of the body weight for 6 to 7 days in treatment of the children with staphylococcal destruction of the lungs, acute and chronic osteomyelitis had no nephrotoxic effect. Combination of kanamycin with pentoxyl, pryimidine derivative significantly improved the kidney function, which was evident from the content of the residual nitrogen in the blood serum and increased glomerural filtration. Combined use of kanamycin with pentoxyl promoted a decrease in albuminuria and leucocyturia. The data of the study provided recommendation of increased therapeutic doses of kanamycin, up to 15000--25000 Units/kg of the body weight in accordance with the recommendations under conditions of constant control of the kidney function.