1.
Practitioner
; 228(1394): 701-2, 1984 Aug.
Article
in English
| MEDLINE
| ID: mdl-6473272
2.
Cancer Chemother Pharmacol
; 12(3): 198-200, 1984.
Article
in English
| MEDLINE
| ID: mdl-6705137
ABSTRACT
This article details a procedure for the analysis of TGU by a simple high-pressure liquid chromatographic (HPLC) method. Linearity is maintained over the range from zero to at least 30 micrograms 1,2,4, triglycidyl urazol (TGU). The sensitivity of the assay is 250 ng/ml. A second peak, as yet unidentified, was detected on the chromatogram and probably represents a metabolite of TGU. The pharmacokinetic profile of TGU in Porton mice shows a first-order elimination process with a half-life (t1/2 alpha) of 1.5 min for the distribution phase and a t1/2 beta of 5 min. The apparent volume of distribution is 0.75 ml and the clearance 0.10 ml/min with a elimination rate constant of 0.14 min.