Differential diagnosis of intracranial ring enhancing cystic mass lesions--role of diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI).

OBJECTIVE: To evaluate the contribution of DWI and DTI to the differential diagnosis of cerebral ring enhancing lesions by describing DWI and ADC (apparent diffusion coefficient) findings and measuring the two DTI parameters mean diffusivity (MD) and fractional anisotropy (FA). MATERIALS AND METHODS: A total of 17 patients presenting with 26 rim enhancing cysts were investigated with DWI and DTI. Parameter maps of the DTI metrics MD and FA were calculated and quantified using regions of interest (ROIs). RESULTS: Five patients suffered from abscesses with a total of 10 cysts, 9 from glioblastomas with 10 cysts, and 3 from metastases with 6 cysts. All abscess cavities showed hyperintense DWI signal intensity compared to normal appearing white matter (NAWM), low ADC, low MD and high FA. Eight out of 10 glioblastoma cysts and all 6 metastatic cysts revealed hypointensity on DWI, high ADC, high MD and low FA (p<0.0001 compared to abscess group). DWI findings of 2/10 glioblastoma cysts overlapped with those of abscesses showing hyperintensity on DWI, low ADC and low MD and hence mimicked abscesses. FA of these 2 glioblastoma cysts was significantly lower than in abscess cavities (p=0.032). CONCLUSION: The findings of reduced diffusion compared to NAWM and increased FA within a ring enhancing cyst strongly indicate a cerebral abscess. In contrast, the majority of neoplastic cysts revealed high diffusion and low FA. Reduced diffusion is also found in a very small number of tumour cysts, but in these low FA refers to a non-infectious origin and thus helps distinguishing from infectious abscess.

Diffusion-weighted MR imaging improves diagnosis of CNS lymphomas. A report of four cases with common and uncommon imaging features.

The frequency of CNS lymphomas is increasing in immunocompetent as well as in immunocompromised patients and its incidence accounts for approximately 1-2% of all primary cerebral neoplasms. It is a challenge to recognize CNS lymphomas by MR imaging as early as possible in order to dispose an optimal therapy. The aim of this report is to demonstrate, how diffusion-weighted MR imaging improves the accuracy of the differential diagnosis of CNS lymphomas.

[Regional lung edema in acute mitral valve insufficiency following chordae tendineae rupture with prolapse of the posterior mitral valve leaflet]. / Regionales Lungenödem bei akuter Mitralinsuffizienz nach Chordae-tendineae-Abriss mit Prolaps des posterioren Mitralsegels.

An unilateral or predominantly lobar pulmonary edema is an unusual clinical or radiological finding, often misdiagnosed as one of the more common causes of focal lung disease. We report 2 cases of a regional pulmonary edema caused by the acute onset of a severe mitral insufficiency after the rupture of chordae tendinae resulting in a prolaps of the posterior mitral leaflet. In both cases the regional pulmonary edema was initially misdiagnosed as a pneumonic infiltration, which delayed the cardiological diagnostical procedures and the surgical intervention. The mechanism of the regional edema is an excentric recurgitation jet into the left atrium, which is usually directed to the orifice of the right upper lobe pulmonary vein which increases the hydrostatic vascular pressure in the corresponding lung segment. For the confirmation of the diagnosis, transesophageal echogradiographic is helpful in documenting the direction of the regurgitant flow and detecting differential gradients between the right and left pulmonary venous systems. The pulmonary infiltrations, which persisted for several weeks, disappeared within a few days after surgical mitral-valve-reconstruction in both cases.