ABSTRACT
It is found that 3 months after removal of thyroid gland in rats, a suppression of thymic endocrine function, loss of weight and cellularity occurs. These changes are mainly caused by a weakening of index of proliferative activity. In animals that postoperatively received substitutive thyroxin hormonotherapy and courses of thymulin these disorders don't occur or they are not expressed significantly.
Subject(s)
Apoptosis/drug effects , Hormone Replacement Therapy , Thymus Gland/drug effects , Thymus Hormones/pharmacology , Thyroidectomy , Thyroxine/pharmacology , Animals , Body Weight/drug effects , Cell Proliferation/drug effects , Male , Organ Size/drug effects , Rats , Thymus Gland/pathology , Thymus Hormones/therapeutic use , Thyroxine/therapeutic useABSTRACT
The effect of thymalin on peroxidation of lipids in thyroidectomized rats that received thyroxin at a dose 2 mg/ kg was examined. It was found that 3 months after operation a decrease in body weight (over 2 times), weight of spleen and amount of cells in it took place. An increase of TB-activated products in livers and spleens of thyroidectomized rats 3 month later was not essential. Indices of enzyme activity of antioxidant system in liver were within normal ranges while indices of activity of catalase and superoxidedysmuthase in spleen increased by 4,3 and 1,3 times, respectively. Simultaneous administration of thyroxin and thymalin promotes more effective normalization of POL peroxidation, inhibits development of pathologic changes in organism after removal of thyroid gland.
Subject(s)
Antioxidants/metabolism , Catalase/metabolism , Hormone Replacement Therapy/methods , Lipid Peroxides/metabolism , Superoxide Dismutase/metabolism , Thyroidectomy , Animals , Body Weight/drug effects , Drug Therapy, Combination , Liver/drug effects , Liver/enzymology , Liver/metabolism , Male , Organ Size/drug effects , Rats , Rats, Wistar , Spleen/drug effects , Spleen/enzymology , Spleen/metabolism , Thymus Hormones/administration & dosage , Thymus Hormones/therapeutic use , Thyroxine/administration & dosage , Thyroxine/therapeutic useABSTRACT
In the livers and spleens of pseudoectomized, thymectomized, thymthyroidectomized mice and thyroidectomized rats there is clear regularity in the change of lipid peroxidation intensity antioxidant system and enzymes activity depending on the severity and duration of pathologic changes occurred in organism and biological significance of the removed endocrine glands in maintenance of homeostasis. Thymostimulin and thyroxin do not render a direct effect on the intensity of lipid peroxidation, but their injection to the thyroidectomized rats indirectly normalizes content of peroxidant products in tissues of liver and spleen and restores disordered metabolism processes as a result of thyroid gland ectomia.
Subject(s)
Antioxidants/metabolism , Glycoproteins/pharmacology , Lipid Peroxidation/drug effects , Thyroxine/pharmacology , Animals , Catalase/metabolism , Liver/drug effects , Liver/metabolism , Mice , Mice, Inbred CBA , Oxidation-Reduction , Rats , Spleen/drug effects , Spleen/metabolism , Superoxide Dismutase/metabolism , Thymectomy , ThyroidectomyABSTRACT
The adaptogenic and antioxidant properties of new Ukrainian plant drug "Poliphytolum" was investigated on the model of stress, which was caused of hypergravitation 2 and 5 N.m2/kg2 action. It was established that hypergravitation makes typical stressory disturbances in oxidative homeostasis. The normalization action of "Polyphytolum" on lipid peroxidation is more strong in liver, spleen and blood, and less more--in brain. It may be caused of low level the drug in the brain tissue.
