ABSTRACT
The causes of development of ischemic heart failure (IHF) are various, its consequence is the non-adequate blood supply to the organs and tissues. A model of the functional respiratory system (FRS) is the most acceptable for the theoretical investigation of the hypoxical states of organism suffering from IHF. For remodeling and determining a degree of damage of coronary vessels, a four-chamber model of the heart was used with coronary vessels leading to each chamber.
Subject(s)
Hypoxia/etiology , Models, Cardiovascular , Myocardial Ischemia/complications , Algorithms , HumansABSTRACT
Research works in high-mountainous areas of Caucasus and, in particular, in Prielbrusie was initiated by N.N. Sirotinin as far back as in 1929. From the beginning the works were done in expeditionary conditions, from 1973--in further organized permanent Elbrus medical and biological station (EMBS). At the present time EMBS is a component of International Center for astronomical, medical and ecological research that was reorganized in 1999. EMBS is a unique scientific subdivision that has no analogues, it is located on different heights of Elbrus Mountain and complex fundamental scientific problems may be solved here using contemporary scientific methods. EMBS includes two-floor laboratory building, thermobaro-chamber, and the center organized for the recovery of patients from ecologically unfavorable regions and increasing of the sportsmen work capacity. Today the new stage of the EMBS activity starts and therefore there is a time to summarize some results of the research works here. Such results of EMBS activity are the fundamental studies in the field of oxygen insufficiency, which reveal the destructive and constructive mechanisms of the hypoxic state development in organisms. Such investigations became the base for the implementation for the first time in the world of the new highly effective methods of hypoxytherapy aimed on the patient treatment, prophylaxis, resistance increasing and improvement of athletic results for the sportsmen. There were suggested and proved the concept of step-by-step adaptation to hypoxia. Hypoxic states developed under the extreme condition influences as well as during different diseases here were studied comprehensively on the different organism levels. The methods of mathematic simulation of hypoxic states with prediction of organism states were elaborated at EMBS too. All these works transformed hypoxia studies from the descriptive-experimental science in exact one.
Subject(s)
Adaptation, Physiological/physiology , Altitude Sickness/physiopathology , Altitude , Biomedical Research , Ecology , Altitude Sickness/etiology , HumansABSTRACT
The health of a person and his capacity for work under conditions of high mountains in many respects is determined by the reliability of the function of physiological systems. Mathematical methods of both the reliability theory and mathematical simulation of basic functional systems are proposed to be used for investigating the reliability. It is shown that the most suitable reliability model for living systems is a chain model-a successive connection of links representing separate functional systems of organism. Besides, the weakest links determining the reliability of functioning of the whole organism under the extreme conditions of high mountains even for a healthy person are-respiration, blood circulation, thermoregulation and psychophysiological systems. Quantitative characteristics of the reliability of these systems are determined through the main indicators. The influence of non-sufficient contents of oxygen in respiration mixture, low atmospheric pressure, low temperatures of the environment are simulated by computer models of organism. An analyses of modeling data shows that moderate physical loading improves indicators of organisms adaptively to external conditions of high mountains and promotes the increasing of persons capacity for work and the reliability of his functioning.
