ABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) produce potent analgesic, antipyretic, and anti-inflammatory effects. We studied postoperative pain in 97 consecutive patients having photorefractive keratectomy (PRK) by an excimer laser with different topical NSAID protocols. Treatment with topical homatropine hydrobromide, either diclofenac sodium (Voltaren Ophthalmic) or ketorolac tromethamine (Acular), and a soft contact lens was most effective in achieving post-PRK analgesia. We also studied post-PRK myopic regression in 68 consecutive patients and found that flurbiprofen sodium (Ocufen), when added to topical steroid protocols, significantly reduced myopic regression for one year postoperatively more than steroids alone or steroids and diclofenac sodium. Diclofenac, used with topical steroids, had less of an additive effect on myopic regression than did flurbiprofen. Topical NSAIDs are useful adjuncts to PRK therapy, both to eliminate postoperative pain and to control post-PRK myopic regression.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Cornea/surgery , Laser Therapy , Pain, Postoperative/prevention & control , Refractive Surgical Procedures , Administration, Topical , Adult , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Follow-Up Studies , Glucocorticoids/administration & dosage , Humans , Middle Aged , Myopia/prevention & control , Pain, Postoperative/etiologyABSTRACT
Authors assayed in vitro 9 toothpastes (signed A to I) against 8 types of microorganisms. Toothpaste D yielded best results, toothpastes A and B shown no antibacterial power; the other ones had intermediate degrees of effectiveness. Authors also performed an in vivo study testing 3 toothpastes on to 5 healthy volunteers, but results are not statistically significant.
Subject(s)
Dentifrices/pharmacology , Toothpastes/pharmacology , Candida/drug effects , Escherichia coli/drug effects , Humans , Microbial Sensitivity Tests , Proteus/drug effects , Saliva/microbiology , Staphylococcus/drug effects , Streptococcus/drug effects , Time Factors , Toothpastes/analysisABSTRACT
We have used three tests of paracoagulation in patients with chronic liver diseases: ethanol test, protamine sulfate test and agglutination test. The best results were obtained with agglutination test specially in liver cirrhosis.
