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Acta Virol ; 57(1): 85-6, 2013.
Article in English | MEDLINE | ID: mdl-23530829

ABSTRACT

We have previously examined the antiviral effects of total alkaloids from Commelina communis L. (TAC). Here we investigated the active constituents of TAC, responsible for the antiviral effect. Harman, homonojirimycin (HNJ) and 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine were isolated from TAC by HPLC. Only HNJ showed strong antiviral activity against influenza A/PR/8/34 virus (H1N1) as measured by cytopathic effect reduction assay. The results suggest that HNJ is one of the active components of TAC.


Subject(s)
1-Deoxynojirimycin/analogs & derivatives , Antiviral Agents/pharmacology , Commelina/chemistry , Influenza A Virus, H1N1 Subtype/drug effects , 1-Deoxynojirimycin/isolation & purification , 1-Deoxynojirimycin/pharmacology , Alkaloids/pharmacology , Animals , Chromatography, High Pressure Liquid , Dogs , Harmine/analogs & derivatives , Harmine/pharmacology , Imino Furanoses/pharmacology , Madin Darby Canine Kidney Cells , Mannitol/analogs & derivatives , Mannitol/pharmacology
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