ABSTRACT
Spontaneous combustion characteristics are important issues for the safe operation of the wet-modified activated carbon drying process. The spontaneous combustion characteristics of activated carbon modified via liquid phase impregnation were fully investigated in this study. The modified activated carbon was prepared using columnar activated carbon and 4-amino-1,2-butanediol solution. Physical properties and surface functional group analyses were performed for activated carbon before and after modification. The ignition temperature of activated carbon before and after modification was then characterized using the methods of GB/T20450-2006, thermogravimetry-derivative thermogravimetry (TG-DTG), and TG-mass spectrometry (TG-MS). At the same time, the activation energy of activated carbon before and after modification was calculated by using thermodynamic analysis. Furthermore, a new self-designed test platform was introduced to investigate the spontaneous combustion characteristics of wet-modified activated carbon under the drying temperatures of 150, 175, 180, and 210 °C. The results show that the specific surface area of Brunauer, Emmett, and Teller (BET) is decreased by 368 m2·g-1, the total volume of pore size is decreased by 0.17 cm3·g-1, and the content of oxygen-containing functional groups is decreased by 0.071 mmol/g compared with row activated carbon. The ignition temperatures of the sample before modification characterized by the three methods are 483, 596, and 599 °C, respectively. The ignition temperatures of the sample after modification are 489, 607, and 611 °C, respectively. The activation energy of the modified activated carbon is increased by 35 kJ/mol compared to the original activated carbon. It is concluded that the temperature that triggers the modified activated carbon combustion during the drying process is between 175 and 180 °C, and the heat is mainly gathered at the longitudinal center of the combustion chamber through the investigation of spontaneous combustion experiments. The results in this study can contribute to safe production to prevent combustion in the process of modifying activated carbon during the drying process.
ABSTRACT
Cellular immune responses are of pivotal importance to understand SARS-CoV-2 pathogenicity. Using an enzyme-linked immunosorbent spot (ELISpot) interferon-γ release assay with wild-type spike, membrane and nucleocapsid peptide pools, we longitudinally characterized functional SARS-CoV-2 specific T-cell responses in a cohort of patients with mild, moderate and severe COVID-19. All patients were included before emergence of the Omicron (B.1.1.529) variant. Our most important finding was an impaired development of early IFN-γ-secreting virus-specific T-cells in severe patients compared to patients with moderate disease, indicating that absence of virus-specific cellular responses in the acute phase may act as a prognostic factor for severe disease. Remarkably, in addition to reactivity against the spike protein, a substantial proportion of the SARS-CoV-2 specific T-cell response was directed against the conserved membrane protein. This may be relevant for diagnostics and vaccine design, especially considering new variants with heavily mutated spike proteins. Our data further strengthen the hypothesis that dysregulated adaptive immunity plays a central role in COVID-19 immunopathogenesis.
Subject(s)
COVID-19 , SARS-CoV-2 , Humans , T-Lymphocytes , Adaptive Immunity , Ataxia Telangiectasia Mutated Proteins , Interferon-gammaABSTRACT
This work is devoted to the development of quantitative structure-property relationship (QSPR) models using various regression analyses to predict propylene (C3H6) adsorption capacity at various pressures in zeolites from a topologically diverse International Zeolite Association database. Based on univariate and multilinear regression analysis, the accessible volume and largest cavity diameter are the most crucial factors determining C3H6 uptake at high and low pressures, respectively. An artificial neural network (ANN) model with five structural descriptors is sufficient to predict C3H6 uptake at high pressures. For combined pressures, the prediction of an ANN model with pore size distribution is pleasing. The isosteric heat of adsorption (Q st) has a significant impact on the improvement of the prediction of low-pressure gas adsorption, which finely classifies zeolites into high or low C3H6 adsorbers. The conjunction of high-throughput screening and QSPR models contributes to being able to prescreen the database rapidly and accurately for top performers and perform further detailed and time-consuming computational-intensive molecular simulations on these candidates for other gas adsorption applications.
ABSTRACT
Professional cleaning and safe social distance monitoring are often considered as demanding, time-consuming, repetitive, and labor-intensive tasks with the risk of getting exposed to the virus. Safe social distance monitoring and cleaning are emerging problems solved through robotics solutions. This research aims to develop a safe social distance surveillance system on an intra-reconfigurable robot with a multi-robot cleaning system for large population environments, like office buildings, hospitals, or shopping malls. We propose an adaptive multi-robot cleaning strategy based on zig-zag-based coverage path planning that works in synergy with the human interaction heat map generated by safe social distance monitoring systems. We further validate the proposed adaptive velocity model's efficiency for the multi-robot cleaning systems regarding time consumption and energy saved. The proposed method using sigmoid-based non-linear function has shown superior performance with 14.1 percent faster and energy consumption of 11.8 percent less than conventional cleaning methods.
Subject(s)
Robotics , HumansABSTRACT
One of the essential attributes of a cleaning robot is to achieve complete area coverage. Current commercial indoor cleaning robots have fixed morphology and are restricted to clean only specific areas in a house. The results of maximum area coverage are sub-optimal in this case. Tiling robots are innovative solutions for such a coverage problem. These new kinds of robots can be deployed in the cases of cleaning, painting, maintenance, and inspection, which require complete area coverage. Tiling robots' objective is to cover the entire area by reconfiguring to different shapes as per the area requirements. In this context, it is vital to have a framework that enables the robot to maximize the area coverage while minimizing energy consumption. That means it is necessary for the robot to cover the maximum area with the least number of shape reconfigurations possible. The current paper proposes a complete area coverage planning module for the modified hTrihex, a honeycomb-shaped tiling robot, based on the deep reinforcement learning technique. This framework simultaneously generates the tiling shapes and the trajectory with minimum overall cost. In this regard, a convolutional neural network (CNN) with long short term memory (LSTM) layer was trained using the actor-critic experience replay (ACER) reinforcement learning algorithm. The simulation results obtained from the current implementation were compared against the results that were generated through traditional tiling theory models that included zigzag, spiral, and greedy search schemes. The model presented in the current paper was also compared against other methods where this problem was considered as a traveling salesman problem (TSP) solved through genetic algorithm (GA) and ant colony optimization (ACO) approaches. Our proposed scheme generates a path with a minimized cost at a lesser time.
ABSTRACT
We have studied reactions between linear Cn(+) (n = 4-9) and D2, using ion mobility mass spectrometry techniques and quantum chemical calculations in order to understand the complex reactivity of the linear cluster cations. Only linear CnD(+) products were observed for the odd (n = 5, 7, 9) linear clusters, while CnD2(+) was the main product for the even clusters. For the reaction rate constants determined for these two channels, we obtained the following two features: (1) the rate constant decreases with the size n, and (2) even-sized clusters have lower rate constants than neighboring odd-sized clusters. In the theoretical calculations using the CCSD(T) and B3LYP methods with the cc-pVTZ basis, we found that a low lying (2)Σ state in odd clusters may play an important role in these reactions. This opposes the previous interpretation that the (2)Πg/u state is the dominant electronic state for linear Cn(+) (n = 4-9) clusters. We showed that a barrierless radical abstraction forming CnD(+) occurs through a direct head on approach for the (2)Σ state Cn(+). In contrast, a carbene-like insertion forming CnD2(+) occurs through a sideways approach for the (2)Πg/u state Cn(+). We have concluded that the higher rate constants for the odd clusters come from the existence of symmetry broken (2)Σ states which are absent in even linear clusters.
ABSTRACT
Three tetra-aryl substituted 1,3-butadiene derivatives with aggregation enhanced emission (AEE) and mechanochromic fluorescence behavior have been rationally designed and synthesized. The results suggest an effective design strategy for developing diverse materials with aggregation induced emission (AIE) and significant mechanochromic performance by employing D-π-A structures with large dipole moments.
ABSTRACT
The objective of this study was to determine if laboratory modules of an undergraduate animal anatomy course offered in distance education (DistEd) format were as effective as face-to-face (F2F) format in helping students learn. Students (n = 159) completed an anatomy pretest as well as a presurvey to assess prior DistEd experience. Alternating each week, laboratory topics were presented either as F2F or as virtual DistEd laboratories. Two laboratory examinations were administered and included material from both laboratory formats (DistEd and F2F). Questions from the pretest were also included and used to generate the posttest scores. At the end of the semester, students completed a postsurvey to determine if DistEd was a viable alternative to F2F. Student grades on each examination were compared using an ANOVA model that included main effects of presentation method (DistEd, F2F), semester (fall, spring), and their interaction. Learning was evaluated based on the performances of students on pre- and posttests using unpaired t-tests. There was an increase (P < 0.0001) in anatomy post- vs. pretest scores for both semesters, indicative of student learning, although there was no effect of presentation method (F2F or DistEd). On exam 1, students achieved greater scores in fall 2008 (P < 0.0001) on material presented via DistEd compared with that presented as F2F. However, in spring 2009 students scored better on material presented as F2F. There was no effect of presentation method on exam 2 scores for either semester. Based on the postsurvey, 79.3% of students in fall 2008 and 52% of students from spring 2009 agreed that DistEd laboratories were a viable alternative to F2F laboratories. The results of this study support the conclusion that anatomy material can be taught effectively by distance education methods.
Subject(s)
Anatomy, Comparative/education , Animals, Domestic/anatomy & histology , Education, Distance , Universities , Animals , Curriculum , North Carolina , Students , Time FactorsABSTRACT
STUDY DESIGN: A randomized, double-blind, placebo-controlled, crossover, multicenter trial. A 1-week baseline period was followed by two treatment periods of 5 weeks duration with levetiracetam increased from 500 mg b.i.d. to a maximum of 1500 mg b.i.d. separated by a 1-week washout period. OBJECTIVES: The objective of the study was primarily to evaluate the efficacy of the anticonvulsant levetiracetam in patients with spinal cord injury (SCI) at- and below-level pain and secondarily to evaluate the effect on spasm severity. SETTING: Outpatients at two spinal cord units and a pain center. METHODS: Patients were allowed to continue their usual pain treatment at a constant dose. The primary outcome measure was the change in median daily pain score (on a 0-10 point numeric rating scale) from 1-week baseline period to the last week of each treatment period. Secondary outcome measures included pain relief of at- and below-level pain, allodynia, spasms and spasticity. RESULTS: A total of 36 patients with SCI at- and or below-level pain were enrolled. Of these, 24 patients completed the trial. We found no effect of levetiracetam on the primary (P=0.46) or any of the secondary outcome measures. Only two patients continued levetiracetam treatment following the trial, and one patient was still in levetiracetam treatment at the 6-month follow-up. Levetiracetam was generally well tolerated with no serious adverse events. CONCLUSIONS: Levetiracetam does not relieve neuropathic pain or spasm severity following spinal cord injury.
Subject(s)
Anticonvulsants/administration & dosage , Pain, Intractable/drug therapy , Piracetam/analogs & derivatives , Spinal Cord Injuries/drug therapy , Adult , Afferent Pathways/drug effects , Afferent Pathways/injuries , Afferent Pathways/physiopathology , Aged , Analgesics/therapeutic use , Cross-Over Studies , Double-Blind Method , Female , Humans , Levetiracetam , Male , Middle Aged , Outcome Assessment, Health Care/methods , Pain Measurement/methods , Pain, Intractable/etiology , Pain, Intractable/prevention & control , Parasympatholytics/therapeutic use , Piracetam/administration & dosage , Spasm/drug therapy , Spasm/etiology , Spasm/prevention & control , Spinal Cord/drug effects , Spinal Cord/physiopathology , Spinal Cord Injuries/complications , Treatment FailureABSTRACT
STUDY DESIGN: Case report. OBJECTIVES: Report a case of rectum perforation during transanal irrigation (TAI). SETTING: Clinic for Spinal Cord Injuries, and Departments of Gastroenterological Surgery and Radiology. CASE REPORT: A 54-year-old woman with spinal cord lesion for 35 years emptied for years her bowel using oral laxative. This became more difficult and took more than 2 h three times a week with reflex stimulation after a chlysma. She wanted to try TAI, and went through the procedure with a nurse one time. The next time she performed the TAI by herself without difficulty. Two hours later she started shivering with a temperature at 38.3 degrees C with normal blood pressure (BP). At rectal exploration, a spoonful fresh blood was found. After another 2 h, she became septic and was transferred to a gastroenterological surgical department. An abdominal X-ray gave no suspicion of free air in the abdomen. Sigmoideoscopy showed 3-5 cm oral to the dentate line a 1 x 1 cm transmural circular lesion. A colon X-ray with water contrast showed a perforation of approximately 2 x 0.5 cm. CONCLUSION: Even in experienced individuals who are proper trained, TAI can cause rectal perforation, which always have to be born in mind.
Subject(s)
Bowen's Disease/drug therapy , Intestinal Perforation/chemically induced , Laxatives/adverse effects , Therapeutic Irrigation/adverse effects , Bowen's Disease/etiology , Female , Humans , Middle Aged , Spinal Cord Injuries/complicationsABSTRACT
Pulmonary epithelium is known to undergo a preneoplastic process prior to the development of lung carcinoma. Squamous dysplasia and atypical adenomatous hyperplasia have been identified and classified as preinvasive lesions of squamous cell carcinoma and peripheral pulmonary adenocarcinoma, respectively. However, these commonly recognized preinvasive lesions do not completely explain the development of all histological types of lung carcinoma. By examining 114 resection lung specimens, we concluded that there are four histological patterns of bronchial epithelial dysplasia based on morphological features (basal cell dysplasia, columnar cell dysplasia, bronchial epithelial dysplasia with transitional differentiation, and squamous dysplasia). The histological patterns were further characterized by immunohistochemistry. Basal cell dysplasia was focally positive for cytokeratin (CK) 17 and 10/13; columnar cell dysplasia was generally positive for CK7, 8, and 18; bronchial epithelial dysplasia with transitional differentiation had a heterogeneous immunoprofile, while squamous dysplasia was positive for CK10/13 and focally positive for CK17. Various degrees of abnormal expression of p53 and Ki-67 were found in the different types of bronchial epithelial dysplasia. The cases were divided into three groups based on degree and extent of bronchial epithelial dysplasia. By Crosstabs McNemar test, the Mann-Whitney U-test (for two independent groups), the Kruskal-Wallis one-way nonparametric ANOVA (for >2 independent groups) and Spearman correlation analysis, the degree and extent of bronchial epithelial dysplasia was shown to be positively correlated with the incidence of bronchogenic carcinoma and multifocal primary lung carcinoma (P<0.05). These findings indicated the following: (1) bronchial epithelium can develop various patterns of dysplasia with abnormal/ambiguous cell differentiation and abnormal expressions of p53 and Ki-67. Thus, these bronchial epithelial dysplastic lesions may represent a preneoplastic process. (2) The degree of bronchial epithelial dysplasia may significantly predispose individuals to bronchogenic carcinoma and multifocal primary lung carcinoma.
Subject(s)
Lung Neoplasms/pathology , Precancerous Conditions/pathology , Adult , Aged , Bronchial Neoplasms/metabolism , Bronchial Neoplasms/pathology , Carcinoma, Bronchogenic/metabolism , Carcinoma, Bronchogenic/pathology , Cell Differentiation , Epithelial Cells/chemistry , Epithelial Cells/pathology , Female , Humans , Immunohistochemistry , Keratins/analysis , Ki-67 Antigen/analysis , Lung Neoplasms/classification , Lung Neoplasms/metabolism , Male , Middle Aged , Precancerous Conditions/classification , Precancerous Conditions/metabolism , Respiratory Mucosa/chemistry , Respiratory Mucosa/pathology , Tumor Suppressor Protein p53/analysisABSTRACT
Field tests of corn co-expressing two new delta-endotoxins from Bacillus thuringiensis (Bt) have demonstrated protection from root damage by western corn rootworm (Diabrotica virgifera virgifera LeConte). The level of protection exceeds that provided by chemical insecticides. In the bacterium, these proteins form crystals during the sporulation phase of the growth cycle, are encoded by a single operon, and have molecular masses of 14 kDa and 44 kDa. Corn rootworm larvae fed on corn roots expressing the proteins showed histopathological symptoms in the midgut epithelium.
Subject(s)
Bacillus thuringiensis/chemistry , Bacterial Proteins/pharmacology , Bacterial Toxins , Endotoxins/pharmacology , Insect Control/methods , Zea mays/metabolism , Animals , Bacillus thuringiensis Toxins , Electrophoresis, Polyacrylamide Gel , Hemolysin Proteins , Immunity, Innate , Immunoblotting , Larva , Models, Genetic , Plants, Genetically Modified , Transformation, GeneticABSTRACT
Forty cases of children with an inhaled foreign body (FB) are reviewed over a three-year period. Clinical data, radiologic findings and complications are detailed. The nature and size of FBs are also reported. Diagnosis and management are discussed according to the most recent studies in the literature. Diagnostic flexible bronchoscopy is a useful first step when the diagnosis is unclear (i.e., choking history, unexplained respiratory symptoms), but FB removal is usually not possible during this procedure. Extraction is performed via the rigid bronchoscope under general anesthesia. However, FB could be removed with the flexible bronchoscope in five children in our study. Diagnosis and removal of an inhaled FB are required as quickly as possible in order to prevent respiratory sequelae (bronchiectasis). Prevention is based upon information to be given to families, but to the medical community as well, which often minimizes the seriousness of inhalation hazards.
Subject(s)
Bronchi , Foreign Bodies , Trachea , Bronchoscopy , Child , Child, Preschool , Female , Foreign Bodies/diagnosis , Foreign Bodies/therapy , Humans , Infant , Infant, Newborn , Male , Respiratory SoundsABSTRACT
A patient suffering from a catecholaminergic polymorph ventricular tachycardia treated with nadolol was scheduled for dental extractions under general anaesthesia. During induction, whereas the basal heart rate was at 30-35 b.min-1, occurred an episode of bidirectional ventricular tachycardia probably induced by the administration of pancuronium.
Subject(s)
Anesthesia, General/methods , Tachycardia, Ventricular/complications , Adult , Anti-Arrhythmia Agents/therapeutic use , Cardiac Complexes, Premature/etiology , Catecholamines/physiology , Electrocardiography, Ambulatory , Female , Humans , Monitoring, Intraoperative , Nadolol/therapeutic use , Stress, Psychological/complications , Tachycardia, Ventricular/drug therapyABSTRACT
This study compared the efficacy and tolerability of sodium cromoglycate (SC) and beclomethasone dipropionate (BDP) in adult patients with bronchial asthma inadequately treated with bronchodilators alone. The study was a double-blind, randomized, double-dummy, parallel-group study. Patients with mild to moderate symptomatic asthma, inadequately treated with bronchodilators only, were, after a 2-week run-in (base-line) period, randomized to 8 weeks of treatment with either SC 10 mg four times daily or BDP 100 micrograms four times daily. Salbutamol metered-dose inhaler was given as relief medication. A total of 37 patients were randomized for treatment, 19 patients in the SC group and 18 patients in the BD group. Efficacy and safety were determined by daily record card data: morning and evening peak-expiratory-flow rates (PEFR), daytime and nighttime asthma symptom scores, and rescue salbutamol use. At clinic visits, FEV1 and FVC were measured, as were the physician's and the patient's assessment of the medication at the end of the study. The safety and tolerability of the trial medication were assessed by monitoring adverse events throughout the study. A clinically and statistically significant improvement of the asthma in FEV1, symptom scores, rescue medication, and global opinion of efficacy was observed, and both groups provided equivalent efficacy. The morning PEFR as well as the evening PEFR for both groups improved, but was statistically significant only for the BDP group (M-PEFR). Both drugs were well tolerated with only a few minor adverse events. This trial shows that SC and BDP are equally effective anti-inflammatory treatments for mild to moderate bronchial asthma in adults.
Subject(s)
Asthma/drug therapy , Beclomethasone/therapeutic use , Cromolyn Sodium/therapeutic use , Adult , Asthma/physiopathology , Beclomethasone/administration & dosage , Beclomethasone/adverse effects , Cromolyn Sodium/administration & dosage , Cromolyn Sodium/adverse effects , Double-Blind Method , Female , Forced Expiratory Volume , Humans , Male , Middle Aged , Nebulizers and Vaporizers , Peak Expiratory Flow RateABSTRACT
The laryngeal mask (LM) is a new concept developed by Brain. Easily inserted, the LM allows appropriate ventilation without the disadvantages of either the facial mask or the endotracheal intubation with its own complications. The limits of its use concern all the cases of reduction of thoracopulmonary compliance and full stomach. The LM offers no protection against regurgitation and aspiration. Airway obstruction may occur following laryngospasm (light anaesthesia) or down folding of the epiglottis. Trauma to the uvula and the posterior pharyngeal wall have been reported. The LM may be useful in all cases of surgery in which intubation is not absolutely required. Moreover, the LM is widely used for ENT and ophthalmic surgeries, in paediatric and adult procedures. Many cases of foreseeable or unforeseeable difficult intubation have been resolved by the insertion of a LM, allowing secondary intubation through the mask. Further investigations are required in order to evaluate the real limits and indications for its extended use.
Subject(s)
Anesthesiology/instrumentation , Larynx , Masks , HumansSubject(s)
Fractures, Bone/prevention & control , Masks , Nose/injuries , Respiratory Protective Devices , Adolescent , Adult , Ambulatory Surgical Procedures , Anesthesia, General , Child , Child, Preschool , Female , Humans , Male , Middle AgedABSTRACT
Kleinschmidt spreading, negative staining, and rotary shadowing were used to examine the large form of (basement membrane) heparan sulfate proteoglycan in the electron microscope. Heparan sulfate proteoglycan was visualized as consisting of two parts: the core protein and, emerging from one end of the core protein, the glycosaminoglycan side chains. The core protein usually appeared as an S-shaped rod with about six globules along its length. Similar characteristics were observed in preparations of core protein in which the side chains had been removed by heparitinase treatment ("400-kDa core") as well as in a 200-kDa trypsin fragment ("P200") derived from one end of the core protein. The core protein was sensitive to lyophilization and apparently also to the method of examination, being condensed following Kleinschmidt spreading (length means = 52 nm) and extended following negative staining (length means = 83 nm) or rotary shadowing (length means = 87 nm; 400-kDa core length means = 80 nm; P200 length means = 44 nm). Two or three glycosaminoglycan side chains (length means = 146 +/- 53 nm) were attached to one end of the core protein. The side chains often appeared tangled or to merge together as one. Thus, the large heparan sulfate proteoglycan from basement membrane is an asymmetrical molecule with a core protein containing globular domains and terminally attached side chains. This structure is in keeping with that previously predicted by enzymatic digestions and with the proposed orientation in basement membranes, i.e., the core protein bound in the lamina densa and the heparan sulfate side chains in the lamina lucida arranged along the surface of the basement membranes.