ABSTRACT
The radiological findings associated with alloimmune thrombocytopenia have not been well described. We present two such cases diagnosed in utero by ultrasound and discuss the radiographic findings of intracranial hemorrhage and hydrocephalus secondary to alloimmune thrombocytopenia. An awareness of this entity and its early diagnosis and intervention may greatly reduce the morbidity and mortality associated with alloimmune thrombocytopenia.
Subject(s)
Autoimmune Diseases/complications , Blood Platelets/immunology , Cerebral Hemorrhage/diagnostic imaging , Fetal Diseases/diagnosis , Hydrocephalus/diagnostic imaging , Thrombocytopenia/immunology , Ultrasonography, Prenatal , Adult , Autoantibodies/analysis , Brain Diseases/diagnostic imaging , Cerebral Hemorrhage/etiology , Cerebral Ventriculography , Dilatation, Pathologic/diagnostic imaging , Female , Humans , Hydrocephalus/etiology , Infant, Newborn , Male , Pregnancy , Thrombocytopenia/complications , Tomography, X-Ray ComputedABSTRACT
Fifteen newborn infants developed roentgenographic evidence of rickets while on long-term intravenous hyperalimentation. In each instance, the initial diagnosis of rickets was suggested on the chest roentgenogram, where characteristic cupped and frayed upper humeral metaphyses were noted; subsequent knee and wrist roentgenograms substantiated these findings. Factors which may have predisposed to the development of rickets include inadequate doses of vitamin D, prematurity and a rapid change in body weight during hyperalimentation therapy.
Subject(s)
Parenteral Nutrition, Total/adverse effects , Parenteral Nutrition/adverse effects , Rickets/etiology , Bone and Bones/diagnostic imaging , Humans , Infant , Infant, Low Birth Weight , Infant, Newborn , Infant, Newborn, Diseases/diagnostic imaging , Infant, Newborn, Diseases/drug therapy , Infant, Newborn, Diseases/etiology , Radiography , Rickets/diagnostic imaging , Rickets/drug therapy , Vitamin D/therapeutic useSubject(s)
Scoliosis/diagnostic imaging , Child , Evaluation Studies as Topic , Humans , RadiographyABSTRACT
An infant, with a normal chest film at birth, shortly thereafter developed hyperinflation of the apical-posterior segment of the left upper lobe due to stenosis of the aberrant bronchus supplying this segment.
