1.
Protein Pept Lett
; 16(12): 1548-56, 2009.
Article
in English
| MEDLINE
| ID: mdl-20001917
ABSTRACT
The potential of human glucagon-like peptide-1 (hGLP-1) as a therapeutic agent is limited by its high aggregation propensity. We show that hGLP-1 forms amyloid-like structures that are preceded by cytotoxic aggregates, suggesting that aggregation of biopharmaceuticals could present a cytotoxic risk to patients besides the reported increased risk in immunogenicity.