1.
Bioorg Med Chem Lett
; 10(13): 1417-20, 2000 Jul 03.
Article
in English
| MEDLINE
| ID: mdl-10888322
ABSTRACT
The contribution of amino acid side chains to the recognition of DNA by peptides or proteins is evaluated by substituting single nucleobases of a DNA double strand by amino acid side chains. C-nucleosides with the side chains of phenylalanine and asparagine were synthesized and incorporated in DNA. This modification should allow to keep the double strand conformation. Hydrogen bonds, pi-pi-interactions and solvation have an influence on the double strand stability.