ABSTRACT
Owing to its subjective nature, behavioral pure-tone audiometry often is an unreliable testing method in uncooperative subjects, and assessing the true hearing threshold becomes difficult. In such cases, objective tests are used for hearing-threshold determination (i.e., auditory brainstem evoked potentials [ABEP] and frequency-specific auditory evoked potentials: slow negative response at 10 msec [SN-10]). The purpose of this study was to evaluate the correlation between pure-tone audiogram shape and the predictive accuracy of SN-10 and ABEP in normal controls and in patients suffering from sensorineural hearing loss (SNHL). One-hundred-and-fifty subjects aged 15 to 70, some with normal hearing and the remainder with SNHL, were tested prospectively in a double-blind design. The battery of tests included pure-tone audiometry (air and bone conduction), speech reception threshold, ABEP, and SN-10. Patients with SNHL were divided into four categories according to audiogram shape (i.e., flat, ascending, descending, and all other shapes). The results showed that ABEP predicts behavioral thresholds at 3 kHz and 4 kHz in cases of high-frequency hearing loss. Also demonstrated was that ABEP threshold estimation at 3 kHz was not affected significantly by audiogram contour. A good correlation was observed between SN-10 and psychoacoustic thresholds at 1 kHz, the only exception being the group of subjects with ascending audiogram, in which SN-10 overestimated the hearing threshold.
Subject(s)
Audiometry, Pure-Tone , Evoked Potentials, Auditory, Brain Stem , Hearing Loss, Sensorineural/diagnosis , Hearing Tests , Acoustic Stimulation , Adolescent , Adult , Aged , Audiometry, Pure-Tone/methods , Auditory Threshold , Female , Hearing Loss, Sensorineural/physiopathology , Humans , Male , Middle AgedABSTRACT
We describe a case of Stevens-Johnson syndrome (SJS) associated with oxaprozin ("Daypro"), a relatively new nonsteroidal antiinflammatory drug (NSAID) of the propionic acid group. Our literature review shows that among the NSAID associated with SJS, oxicams have the highest risk. The risk is low for the propionic acid group. Indeed, the prevalence of their use was too low to permit an analysis of individual drugs. This is the first reported case of SJS associated with oxaprozin. Although the patient we describe survived the reaction, we think it is important to report such a potentially fatal reaction to a relatively newly available medication.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Propionates/adverse effects , Stevens-Johnson Syndrome/chemically induced , Arthritis, Rheumatoid/drug therapy , Female , Humans , Middle Aged , Oxaprozin , Stevens-Johnson Syndrome/diagnosisABSTRACT
A comparative study was performed with 51 patients, using the stapedial reflex (ART), early auditory brain-stem responses (ABR), later auditory evoked potentials (SN10) and the audiogram, to assess the value of objective tests in the evaluation of the auditory level. The ABR and the SN10 are valid to determine the level of hearing. The ART s of limited value.
