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Biochemistry ; 53(26): 4225-7, 2014 Jul 08.
Article in English | MEDLINE | ID: mdl-24955650

ABSTRACT

Living cells contain a range of densely phosphorylated surfaces, including phospholipid membranes, ribonucleoproteins, and nucleic acid polymers. Hyperphosphorylated surfaces also accumulate in neurodegenerative diseases as neurofibrillar tangles. We have synthesized and structurally characterized a precisely patterned phosphotyrosine surface and establish this assembly as a surrogate of the neuronal tangles by demonstrating its high-affinity binding to histone H1. This association with nucleic acid binding proteins underscores the role such hyperphosphorylated surfaces may play in disease and opens functional exploration into protein-phosphorylated surface interactions in a wide range of other complex assemblies.


Subject(s)
Histones/chemistry , Nanotubes, Peptide/chemistry , Phosphotyrosine/chemistry , Animals , Humans , Nanotubes, Peptide/ultrastructure
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