[Selected markers in early prediction of preeclampsia]. / Vybrané markery v skorej predikcii preeklampsie.

OBJECTIVE: Review of actual trends in early prediction of preeclampsia. SUBJECT: Literature review. SETTING: Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic. SUBJECT AND METHOD: Literature review of markers used in early prediction of preeclampsia. Review of their reliability and possible advantage of combination. CONCLUSION: Preeclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. Onset of clinic symptomes of preeclampsia can appear after 20 weeks of gestation. To find a single marker, or their combination, in early prediction of preeclampsia is one of the goals of modern perinatology. We look at some of the potential markers, which can fulfil these criteria.

[Streptococci group B in perinatology]. / Streptokoky skupiny B v perinatológii.

OBJECTIVE: Assessment of screening and prophylaxis of streptococci group B (GBS). DESIGN: Retrospective study. SETTING: Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic. METHODS: Groups of patients: A-GBS negative (n=601), B-GBS positive (n=166), and C-unknown GBS status (n=238). RESULTS: We assessed 1005 deliveries; antenatal screening was done in 767 patients (166 GBS positive). Intrapartal antibiotic prophylaxis (IAP) was the most frequent in group B (75.3%), (A-10.0%, C-15.0%). The most common antibiotics: ampicillin, and cephalosporins of the 1st and 2nd generation. The interval from rupture of membranes (ROM) to the first IAP dose was significantly the shortest in group B. The longest interval from ROM to delivery was in group A (490 min.). CONCLUSION: This study shows the possibilities for improvement in GBS prophylaxis, in unknown GBS status, and preterm delivery, particularly.