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1.
Nat Med ; 24(10): 1625-1626, 2018 Oct.
Article in English | MEDLINE | ID: mdl-30013196

ABSTRACT

In the version of this article initially published, the line graph showing TNF-α levels in Fig. 2d was inadvertently duplicated. A graph of IL-6 levels should be shown in place of the duplication.These results were also incorrectly described in the main text, which originally stated: "At an early time point of infection (6 h), RTX-treated mice showed higher induction of total inflammatory-protein levels in the bronchoalveolar lavage fluid (BALF) (Fig. 2c), as well as levels of the cytokines TNF-α and IL-6, and the chemokine CXCL-1 (Fig. 2d)". This should instead read: "At an early time point of infection (6 h), RTX-treated mice showed higher induction of total inflammatory-protein levels in the bronchoalveolar lavage fluid (BALF) (Fig. 2c), as well as levels of the cytokine TNF-α and the chemokine CXCL-1 (Fig. 2d)".In the supplementary information initially posted online, incorrect bar graphs were presented in Supplementary Fig. 1b (VG, TRPV1+ data, top panel) and Supplementary Fig. 4b (DRG, CGRP+ data, middle panel).

2.
Nat Med ; 24(4): 417-426, 2018 05.
Article in English | MEDLINE | ID: mdl-29505031

ABSTRACT

Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonary host defense is unclear. Here, we found that TRPV1+ nociceptors suppressed protective immunity against lethal Staphylococcus aureus pneumonia. Targeted TRPV1+-neuron ablation increased survival, cytokine induction, and lung bacterial clearance. Nociceptors suppressed the recruitment and surveillance of neutrophils, and altered lung γδ T cell numbers, which are necessary for immunity. Vagal ganglia TRPV1+ afferents mediated immunosuppression through release of the neuropeptide calcitonin gene-related peptide (CGRP). Targeting neuroimmunological signaling may be an effective approach to treat lung infections and bacterial pneumonia.


Subject(s)
Bacterial Infections/immunology , Neutrophils/metabolism , Nociceptors/metabolism , Pneumonia/immunology , Receptors, Antigen, T-Cell, gamma-delta/metabolism , Sensory Receptor Cells/metabolism , T-Lymphocytes/immunology , Animals , Bacterial Infections/microbiology , Calcitonin Gene-Related Peptide/metabolism , Cytokines/metabolism , Female , Host-Pathogen Interactions/immunology , Male , Mice, Inbred C57BL , NAV1.8 Voltage-Gated Sodium Channel/metabolism , Pneumonia/microbiology , Pneumonia/pathology , Staphylococcal Infections/microbiology , Staphylococcal Infections/pathology , Staphylococcus aureus/physiology , TRPV Cation Channels/metabolism , Vagus Nerve/metabolism
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