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Z Kardiol ; 68(10): 700-4, 1979 Oct.
Article in German | MEDLINE | ID: mdl-160146

ABSTRACT

Electrophysiological effects of the atropin ester Ipatropiumbromide (SCH 1000) were investigated in 15 patients by His electrocardiography and high frequency atrial stimulation. Heart rate increased by 50% of base line heart rate, PA- and AH-intervals and sinus node recovery time decreased, the HF-interval remained unchanged. Physiological av-block by atrial stimulation occurred at significant higher stimulation frequencies with SCH 1000 than without medication. Additional 15 patients were treated for a longer follow-up period. Increase of resting heart rate averaged 15%. Equivocal effects on heart rate were found with exercise after SCH 1000. Non-cardiac side effects were found in 5 patients.


Subject(s)
Atropine Derivatives/therapeutic use , Bradycardia/drug therapy , Bundle of His/drug effects , Heart Conduction System/drug effects , Ipratropium/therapeutic use , Adult , Aged , Electric Stimulation , Electrophysiology , Female , Heart Atria , Heart Rate/drug effects , Humans , Male , Middle Aged
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