ABSTRACT
With the present study we investigated both the presence of cytoplasmic estrogen (E-Rc) and progesterone (P-Rc) receptor, nuclear E-R (E-Rn) and the percentage of cycling tumor cells with Ki-67 MAB in 32 CNS tumor specimens. The main purpose of our study was to evaluate a possible correlation between the hormonal and kinetic parameters and the clinical and neuroradiological follow-up.
Subject(s)
Brain Neoplasms/chemistry , Nuclear Proteins/analysis , Receptors, Estrogen/analysis , Receptors, Progesterone/analysis , Adolescent , Adult , Aged , Brain Neoplasms/mortality , Brain Neoplasms/pathology , Cell Nucleus/chemistry , Cytoplasm/chemistry , Female , Humans , Ki-67 Antigen , Male , Middle Aged , PrognosisABSTRACT
The authors report their personal series of 100 consecutive surgically treated single brain metastases between 1981 and 1988. Patients selection was decided with respect to general and neurological conditions and to primary cancer development. Resection was mostly radical, postoperative mortality rate was 6% and neurological improvement was obtained in 73% of cases. Mean follow-up was 15 months (min. 12, max. 60). The overall median survival time was 13 months. The survival rate was studied with respect to age, lesion site, preoperative syndrome, primary cancer, cause of death and radiotherapy. On the base of their experience the Authors would stress that a better patients selection can further reduce the mortality rate.
