ABSTRACT
Machine learning algorithms can be trained to estimate age from brain structural MRI. The difference between an individual's predicted and chronological age, predicted age difference (PAD), is a phenotype of relevance to aging and brain disease. Here, we present a new deep learning approach to predict brain age from a T1-weighted MRI. The method was trained on a dataset of healthy Icelanders and tested on two datasets, IXI and UK Biobank, utilizing transfer learning to improve accuracy on new sites. A genome-wide association study (GWAS) of PAD in the UK Biobank data (discovery set: [Formula: see text], replication set: [Formula: see text]) yielded two sequence variants, rs1452628-T ([Formula: see text], [Formula: see text]) and rs2435204-G ([Formula: see text], [Formula: see text]). The former is near KCNK2 and correlates with reduced sulcal width, whereas the latter correlates with reduced white matter surface area and tags a well-known inversion at 17q21.31 (H2).
Subject(s)
Aging , Brain/diagnostic imaging , Brain/physiology , Deep Learning , Adolescent , Adult , Aged , Aged, 80 and over , Databases, Factual , Genome-Wide Association Study , Humans , Iceland , Magnetic Resonance Imaging , Middle Aged , Neural Networks, Computer , Neuropsychological Tests , Polymorphism, Single Nucleotide , United Kingdom , Young AdultABSTRACT
We present association results from a large genome-wide association study of tooth agenesis (TA) as well as selective TA, including 1,944 subjects with congenitally missing teeth, excluding third molars, and 338,554 controls, all of European ancestry. We also tested the association of previously identified risk variants, for timing of tooth eruption and orofacial clefts, with TA. We report associations between TA and 9 novel risk variants. Five of these variants associate with selective TA, including a variant conferring risk of orofacial clefts. These results contribute to a deeper understanding of the genetic architecture of tooth development and disease. The few variants previously associated with TA were uncovered through candidate gene studies guided by mouse knockouts. Knowing the etiology and clinical features of TA is important for planning oral rehabilitation that often involves an interdisciplinary approach.
Subject(s)
Anodontia/genetics , Anodontia/epidemiology , Anodontia/etiology , Female , Genome-Wide Association Study , Humans , Iceland/epidemiology , Male , Polymorphism, Single Nucleotide/genetics , Risk FactorsABSTRACT
Several copy number variants have been associated with neuropsychiatric disorders and these variants have been shown to also influence cognitive abilities in carriers unaffected by psychiatric disorders. Previously, we associated the 15q11.2(BP1-BP2) deletion with specific learning disabilities and a larger corpus callosum. Here we investigate, in a much larger sample, the effect of the 15q11.2(BP1-BP2) deletion on cognitive, structural and functional correlates of dyslexia and dyscalculia. We report that the deletion confers greatest risk of the combined phenotype of dyslexia and dyscalculia. We also show that the deletion associates with a smaller left fusiform gyrus. Moreover, tailored functional magnetic resonance imaging experiments using phonological lexical decision and multiplication verification tasks demonstrate altered activation in the left fusiform and the left angular gyri in carriers. Thus, by using convergent evidence from neuropsychological testing, and structural and functional neuroimaging, we show that the 15q11.2(BP1-BP2) deletion affects cognitive, structural and functional correlates of both dyslexia and dyscalculia.
Subject(s)
Cognition/physiology , DNA Copy Number Variations/genetics , Dyscalculia/genetics , Dyslexia/genetics , Intellectual Disability/genetics , Adolescent , Adult , Aged , Chromosome Aberrations , Chromosome Deletion , Chromosomes, Human, Pair 15/genetics , Developmental Disabilities/genetics , Female , Functional Neuroimaging/methods , Functional Neuroimaging/standards , Heterozygote , Humans , Iceland/epidemiology , Magnetic Resonance Imaging/methods , Male , Middle Aged , Neuropsychological Tests/standards , Phenotype , Temporal Lobe/anatomy & histology , Temporal Lobe/diagnostic imaging , Young AdultABSTRACT
Using Icelandic whole-genome sequence data and an imputation approach we searched for rare sequence variants in CHRNA4 and tested them for association with nicotine dependence. We show that carriers of a rare missense variant (allele frequency=0.24%) within CHRNA4, encoding an R336C substitution, have greater risk of nicotine addiction than non-carriers as assessed by the Fagerstrom Test for Nicotine Dependence (P=1.2 × 10(-4)). The variant also confers risk of several serious smoking-related diseases previously shown to be associated with the D398N substitution in CHRNA5. We observed odds ratios (ORs) of 1.7-2.3 for lung cancer (LC; P=4.0 × 10(-4)), chronic obstructive pulmonary disease (COPD; P=9.3 × 10(-4)), peripheral artery disease (PAD; P=0.090) and abdominal aortic aneurysms (AAAs; P=0.12), and the variant associates strongly with the early-onset forms of LC (OR=4.49, P=2.2 × 10(-4)), COPD (OR=3.22, P=2.9 × 10(-4)), PAD (OR=3.47, P=9.2 × 10(-3)) and AAA (OR=6.44, P=6.3 × 10(-3)). Joint analysis of the four smoking-related diseases reveals significant association (P=6.8 × 10(-5)), particularly for early-onset cases (P=2.1 × 10(-7)). Our results are in agreement with functional studies showing that the human α4ß2 isoform of the channel containing R336C has less sensitivity for its agonists than the wild-type form following nicotine incubation.
Subject(s)
Genetic Predisposition to Disease , Mutation, Missense , Receptors, Nicotinic/genetics , Smoking/genetics , Tobacco Use Disorder/complications , Tobacco Use Disorder/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Aortic Aneurysm, Abdominal/etiology , Aortic Aneurysm, Abdominal/genetics , Female , Genetic Association Studies , Humans , Iceland , Lung Neoplasms/etiology , Lung Neoplasms/genetics , Male , Middle Aged , Peripheral Arterial Disease/etiology , Peripheral Arterial Disease/genetics , Pulmonary Disease, Chronic Obstructive/etiology , Pulmonary Disease, Chronic Obstructive/genetics , White People/genetics , Young AdultABSTRACT
HeartCare is an Internet-based information and support service for patients recovering at home from coronary artery bypass graft (CABG) surgery. The system is designed to meet the nursing challenges in health information to support needs of CABG patients. HeartCare (a) provides information and support, tailored to patients' individual and changing recovery needs during CABG recovery, (b) makes recovery information more accessible for timely use by patients, and (c) extends the scope of nursing services to CABG patients from hospital through home. An ongoing randomized controlled study is underway to evaluate the clinical outcomes of patients' use of the HeartCare system and to examine its acceptance as a usable resource for postCABG patients who have limited previous computer experience.
Subject(s)
Coronary Artery Bypass/rehabilitation , Home Care Services/organization & administration , Internet/organization & administration , Patient Education as Topic/organization & administration , Social Support , Adult , Aged , Aged, 80 and over , Computer-Assisted Instruction , Convalescence , Coronary Artery Bypass/adverse effects , Coronary Artery Bypass/nursing , Coronary Artery Bypass/psychology , Curriculum , Female , Humans , Longitudinal Studies , Male , Middle Aged , Needs Assessment , Patient Satisfaction , Program EvaluationABSTRACT
Using a theoretical framework of social support, and content analysis, the content and pattern of support in messages posted in a 4-week period on a commercial health network for individuals concerned with heart disease were observed and described. Special consideration was given to identifying gender differences.
