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Am J Trop Med Hyg ; 71(2): 187-9, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15306708

ABSTRACT

It was reported in 1946 that the administration of pamaquine during the incubation period delayed but did not prevent primary attacks of a New Guinea strain of Plasmodium vivax malaria. The observation that none of the four test subjects in this study had relapses has not previously been published and may have important implications for the evaluation of other 8-aminoquinoline compounds against relapsing vivax malaria.


Subject(s)
Aminoquinolines/history , Antimalarials/history , Malaria, Vivax/history , Plasmodium vivax/drug effects , Aminoquinolines/therapeutic use , Animals , Antimalarials/therapeutic use , Australia , Clinical Trials as Topic/history , History, 20th Century , Humans , Malaria, Vivax/drug therapy , Malaria, Vivax/prevention & control , Military Personnel/history , Plasmodium vivax/growth & development , Secondary Prevention , Sporozoites/pathogenicity
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