Subject(s)
Antineoplastic Agents/adverse effects , Cladribine/adverse effects , Lung Diseases, Interstitial/chemically induced , Respiratory Insufficiency/chemically induced , Aged , Antineoplastic Agents/therapeutic use , Cladribine/therapeutic use , Female , Humans , Lung Diseases, Interstitial/diagnostic imaging , Lymphoma, Non-Hodgkin/drug therapy , Respiratory Insufficiency/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Histologic evidence of venous thrombosis and lipid abnormalities have previously been reported in osteoarthritis. Hypofibrinolysis has been recorded in patients with ischemic necrosis of bone, and it has been proposed as a major cause of osteonecrosis. This study determines whether systemic evidence of coagulation and lipid abnormalities could be detected in osteoarthritis. Global and specific tests were used to assess coagulability and fibrinolysis in 44 patients with degenerative osteoarthritis of the hip and 52 matched control subjects. In patients with osteoarthritis, an increase in factor VIIlc, increased platelet sensitivity over a range of adenosine diphosphate concentrations (0.05 micromol/L-4 micromol/L) and elevated D dimer levels were found. Euglobulin clot lysis time was prolonged in this group and plasminogen activator inhibitor Type 1 activity was increased. Relative hyperlipidemia was observed in the osteoarthritis group, with increased cholesterol, low density lipoprotein cholesterol, and triglyceride levels. It is concluded that there is a hypercoagulable and prothrombotic condition in osteoarthritis, with hypofibrinolysis and indirect evidence of increased fibrin generation. The possible contribution of lipid abnormalities to hemostatic imbalance in osteoarthritis is discussed.
Subject(s)
Blood Coagulation Disorders/physiopathology , Fibrinolysis , Osteoarthritis/physiopathology , Aged , Blood Coagulation Disorders/blood , Blood Coagulation Tests , Female , Humans , Hyperlipidemias/blood , Hyperlipidemias/physiopathology , Lipids/blood , Male , Osteoarthritis/bloodABSTRACT
Experience with 16 sequential patients with Stage IA/IIA supradiaphragmatic Hodgkin's disease who had no evidence of intra-abdominal disease using high-dose gallium and computerized tomography scanning is reported. Subsequent staging laparotomy also was negative in all these patients and did not alter management decisions. It is suggested that high-dose, whole-body gallium scanning and other noninvasive staging procedures give reliable data for therapeutic decisions.
Subject(s)
Diaphragm/diagnostic imaging , Gallium Radioisotopes , Hodgkin Disease/diagnostic imaging , Thoracic Neoplasms/diagnostic imaging , Adult , Female , Humans , Laparotomy , Lymphatic Metastasis , Male , Neoplasm Staging , Prospective Studies , Radionuclide Imaging , Tomography, X-Ray ComputedABSTRACT
Three patients who were taking co-trimoxazole developed acute pancytopenia due to megaloblastic arrest, and two of the three died while pancytopenic. One patient had a pre-existing megaloblastic anaemia. In the other two patients, there was no macrocytosis or neutrophil hypersegmentation despite the severe megaloblastosis. Because specific treatment is needed urgently, it is important to distinguish megaloblastic arrest from drug-induced hypoplasia.
