ABSTRACT
The selectivity and retention properties of a zirconia stationary phase were reversibly altered using various ligands containing Lewis base functional groups. A simple loading procedure allowed a variety of ligands to be attached to the zirconia surface via Lewis interactions. The resulting stationary phases were shown to be stable and produced different selectivity and retention properties from the native zirconia material. The metal oxide adsorbent was converted to a diol-type stationary phase using glucose-6-phosphate for use under normal-phase conditions. Reversed-phase supports were produced by loading either octyl- or octadecylphosphonic acid onto the native zirconia support. The properties of these new phases were then compared to commercially available bonded silica analogs. Ligands bound to the surface in this manner were effectively removed and the native zirconia was regenerated using a dilute base wash procedure.
