ABSTRACT
Practical application of turbidimetrical method for the diagnosis of haemostasis disorders in babies with acute intestinal infections (AII) is described. The results of plasma biochemical analysis show that disturbances in balance between coagulation and fibrinolytic systems takes place in patients with this pathology. The correlation between biochemical parameters and clinical characteristics is observed. As follows from our data, the phase of the haemostasis disorders in babies with AII does not depend on etiology of the disease, but indicates its severity.
Subject(s)
Hemostasis , Intestinal Diseases/diagnosis , Nephelometry and Turbidimetry , Adolescent , Blood Coagulation Disorders/diagnosis , Case-Control Studies , Child , Child, Preschool , Fibrinolysis/physiology , Humans , Infant , Intestinal Diseases/bloodABSTRACT
Homologous interferons (IF) of the 1st and 2nd types are studied for their effect on the course of experimental staphylococcal infection. A model of intracutaneous infection of animals is used. Survival of mice, dynamics of the agent elimination from the organism, functional activity of phagocytes in dynamics of the infectious process during IF administration are studied. Only preparations of natural IF are found to possess a protective effect. The recombinant gamma-IF does not prevents from the mouse death and exerts no effect on the dynamics of elimination of agents from the organism.
Subject(s)
Interferon-alpha/administration & dosage , Interferon-gamma/administration & dosage , Staphylococcal Infections/therapy , Animals , Drug Evaluation, Preclinical , Mice , Mice, Inbred BALB C , Neutrophils/drug effects , Neutrophils/immunology , Phagocytosis/drug effects , Recombinant Proteins , Staphylococcal Infections/immunology , Staphylococcal Infections/mortality , Time FactorsABSTRACT
The effect of type I interferon (IF) on the course of endotoxic shock was studied by morphological methods. It was found that preliminary (24 hours earlier) injection of preparations of homologous IF (10(3) ME) to ABLb/c and CC57 W mice sensitive to salmonella infection prevented the death of 90% of animals from a lethal toxic dose of the endotoxin or killed salmonellae. Preliminary injection of IF reduced sharply the intensity of morphological changes during all periods of the study. IF mitigates the toxic effect exerted on the cell and tissue structure both by increasing the functional activity of phagocytes, facilitating in this way elimination of the endotoxin from the body, and by increasing cell resistance to the direct effect of the bacterial toxin, which is just what determines its protective antitoxic effect. It was established that IF prevents the development of the most grave changes--thrombosis of the microcirculatory bed of vitally important organs by hindering the development of disseminated intravascular coagulation of blood, which determines the severity and outcome of shock.
Subject(s)
Interferon Type I/therapeutic use , Shock, Septic/therapy , Animals , Male , Mice , Mice, Inbred BALB C , Mice, Inbred StrainsABSTRACT
The present study has revealed that persons working at offal and bone processing plants show no specific pathology, peculiar to such plants, in the state of their health and severe mass diseases among these persons are absent. Nevertheless, rather frequent occurrence of erysipeloid should be noted. The survey of workers employed at different stages of the production process has revealed the presence of ornithosis, listeriosis and leptospirosis infections. No clinically manifest cases of these diseases have been detected. The infection of individual workers occurs in the process of production as the result of contacts with infected raw materials of animal origin. For preventing the possible spread of infection great attention should be paid to sanitary, hygienic and epidemiological measures.
