[Morphological changes in the mucosa of the stomach and the small intestine of rats under the action of mebendazole]. / Morfologicheskie izmeneniia slizistoi obolochki zheludka i tonkoi kishki krys pod deistviem mebendazola.

The effect of mebendazole on the gastric and intestinal mucosa was studied in 52 intact white rats. It was shown that the drug caused a significant damage to the mucosa, especially of goblet cells of villi and crypts and interfere with the mucoid secretion. The alterations after mebendazole administration were more severe than those caused by naphthamon. On the 13-15th day after the treatment the complete restoration of the damage was not seen.

[Changes in the indices of the B-immunity system in patients with intestinal nematodiases after treatment]. / Izmenenie pokazatelei B-sistemy immuniteta u bol'nykh kishechnymi nematodozami posle lecheniia.

A decrease in the titers of antibodies to opportunistic bacteria has been observed in 100 patients suffering from ascariasis, trichocephaliasis and mixed invasion (ascariasis and trichocephaliasis). The immune suppression was higher in patients with mixed invasion. Medamine treatment enhances the suppression of antibody production. Changes in humoral immunity parameters are due to the effect of helminthic antigens and the composition of Escherichia in the large intestine of the affected subjects.

[Microparasitocenosis of the intestines and the activity of intestinal enzymes in patients with trichocephaliasis during treatment]. / Mikroparazitotsenoz kishechnika i aktivnost' kishechnykh fermentov u bol'nykh trikhotsefalezom v protsesse lecheniia.

Results of the studies of large intestine microflora, enterokinase and alkaline phosphatase activity in the feces of 298 children and adults suffering from trichocephaliasis are presented. Intestinal dysbacteriosis was observed in 51.7% cases, increased enterokinase activity, in 57.6% cases and increased alkaline phosphatase activity, in 55% cases. Enteric enzyme activity relation to the state of enteric microflora is demonstrated. Specific bephenium hydroxynaphthoate and mebendazole treatment was followed by increased dysbacteriosis and higher intestinal enzyme activity, especially in case of bephenium hydroxynaphthoate treatment. Normalization of the above-mentioned parameters was observed 90-120 days after the end of the treatment.