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A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism.
RSC Adv
; 13(43): 29862-29865, 2023 Oct 11.
Article
in English
| MEDLINE
| ID: mdl-37842681
ABSTRACT
We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs.