ABSTRACT
Oral and maxillofacial pathology, the branch of dentistry concerning clinical and histopathological diagnosis of pathologies of the oral and maxillofacial region, started to develop in Colombia in the mid- 19th century. Since 1950s, dedicated dental clinicians from different dental schools played an important role in its inception and subsequent development. The first significant wave of progress occurred in the 1970s with the appearance of the first formally trained oral pathologists. It was sometime in the late 1980s and early 1990s that dentists Ines Velez and Benjamin Herazo had separate initiatives and created the first oral pathology postgraduate programs in Bogotá. It was in the late 80's and early 90's that dentists Ines Velez and Benjamin Herazo had their own initiatives and created the first oral pathology postgraduate programs in the city of Bogotá. A concomitant of their achievements was the establishment of the first on-site oral pathology biopsies units and registers at Colegio Odontãlogico Colombiano, Pontificia Universidad Javeriana and Escuela Colombiana de Medicina dental schools. The programs have trained many dentists in the field over the years and two of them remain active and fully accredited. The past and present contributions and leaderships of some academic figures and graduates have allowed a steady evolution of the specialty nationwide. Currently, the ability to manage and overcome educational and professional challenges is necessary to advance the growth of this specialty in this country.
Subject(s)
Medicine , Pathology, Oral , ColombiaABSTRACT
Background:Immunohistochemistry have had a huge impact on oral and maxillofacial pathology diagnosis. As a method it determines distribution and amount of certain cellular molecules via specific antigen-antibody reaction. Whereas in most cases a definitive diagnosis is achieved based on detailed hematoxylin and eosin cytomorphological analysis, along with clinical and radiological features, some challenging and equivocal neoplasms need to be further assessed with immunohistochemistry. Objective:This article reviews and updates immunohistochemistry technique fundamentals, its role and relevance in the diagnosis of common oral and maxillofacial lesions encountered in daily practice. Materials and methods: A literature review on the topic was carried out by searching pertinent and available papers on PubMed, ClinicalKey and Scielo platforms with no date restriction, up to 2022. Conclusion: Immunohistochemistry is an important tool that has been integrated into conventional histopathology and provides diagnostic assistance in the interpretation of common but equivocal neoplasms
Antecedentes: El uso de la inmunohistoquímica ha tenido un gran impacto en el diagnóstico de patología oral y maxilofacial. Como técnica, determina la distribución y la cantidad de ciertas moléculas celulares a través de una reacción antígeno-anticuerpo específica. Aunque en la mayoría de los casos se logra obtener un diagnóstico definitivo basado en el análisis cito morfológico con hematoxilina y eosina, junto con las características clínicas y radiológicas, algunas neoplasias microscópicamente equívocas deben evaluarsemás a fondo con inmunohistoquímica. Objetivo: Este artículo revisa los fundamentos básicos actuales de la técnica y su relevancia en el diagnóstico de algunas lesiones orales y maxilofaciales frecuentemente tratadas en la práctica clínica diaria. Materiales y Métodos: Se realizó una búsqueda y revisión de artículos científicos relacionados con el uso immunohistoquímica en patología oral y maxilofacial en PubMed, ClinicalKey y Scielo. Conclusión: La immunohistoquimica es una herramienta importante que ha sido integrada a la histopatología convencional y brinda asistencia diagnostica en la interpretación de neoplasias comunes pero equívocas
