ABSTRACT
BACKGROUND: An increasing number of papers have documented the contribution of chronic periodontitis (P) to the pathogenesis of cardiovascular disease. The aim of this study was to answer the question whether there is an association between periodontal inflammation and atherosclerotic processes in hemodialysis patients with chronic kidney disease (CKD). METHODS: Forty-four hemodialysis patients with CKD were considered. Advanced chronic periodontitis was found in 17, whereas 27 patients had no or moderate chronic periodontitis. In all patients examined, serum C-reactive protein (CRP), TNF-alfa and IL-6 concentrations, as well as intima-media thickness (IMT) of the carotid artery, were assessed. RESULTS: Patients with CKD and advanced periodontitis were characterized by a significantly higher serum CRP concentration (13.2 +/- 11.4 vs. 10.4 +/- 14.4; p<0.05) and IMT (0.742 +/- 0.028 vs. 0.656 +/- 0.019, p<0.05) than CKD patients without periodontitis. In the univariate analysis, a significant correlation between CRP and number of atherosclerotic plaques was revealed; however, it was not confirmed as an independent relationship in the multiple regression analysis. CONCLUSIONS: Inflammation of the periodontal tissue in patients with CKD is associated with increased serum CRP concentration and greater IMT. It is possible that periodontitis may induce a systemic process that may exacerbate atherosclerosis.
Subject(s)
C-Reactive Protein/metabolism , Carotid Arteries/diagnostic imaging , Kidney Diseases/complications , Periodontitis/blood , Periodontitis/diagnostic imaging , Renal Dialysis , Adult , Chronic Disease , Female , Humans , Kidney Diseases/blood , Kidney Diseases/diagnostic imaging , Male , Middle Aged , Periodontitis/complications , Tunica Intima/diagnostic imaging , Tunica Media/diagnostic imaging , UltrasonographyABSTRACT
UNLABELLED: The present study aimed to assess the oral hygiene in haemodialyzed patients with chronic renal failure (CRF). MATERIAL AND METHODS: 44 haemodialyzed patients with CRF were analyzed (18 F and 26 M, mean age 47.4 +/- 1.6). In all patients a stomatological examination and dental panoramic x-ray were performed. The presence of chronic periodontal disease (CP) and an approximal plaque index (API) were assessed. RESULTS: Chronic periodontitis was found in 17 patients (39%), whereas in 27 (61%) patients periodontal disease was not present. Oral hygiene assessed by API was not satisfactory in 50%, while very good only in 11% haemodialyzed patients. Patients with periodontal disease were characterized by worse API than patients without periodontitis. CONCLUSION: Oral hygiene status is unsatisfactory in most of haemodialyzed uremic patients.
