Subject(s)
Anaphylaxis/chemically induced , Excipients/adverse effects , Polysorbates/adverse effects , Adrenal Cortex Hormones/administration & dosage , Anaphylaxis/diagnosis , Anaphylaxis/drug therapy , Anaphylaxis/immunology , Anti-Allergic Agents/therapeutic use , Drug Compounding , Female , Humans , Injections, Intramuscular , Intradermal Tests , Low Back Pain/drug therapy , Middle Aged , Predictive Value of Tests , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Middle Aged , Polysorbates/adverse effects , Polysorbates/analysis , Excipients/adverse effects , Excipients/therapeutic use , Anaphylaxis/chemically induced , Anaphylaxis/diagnosis , Adrenal Cortex Hormones/adverse effects , Adrenal Cortex Hormones/therapeutic use , Skin Tests/methods , Skin Tests , Drug Hypersensitivity/complications , Drug Hypersensitivity/diagnosisABSTRACT
BACKGROUND AND OBJECTIVE: Contradictory reports of the sensitivity of skin tests in quinolone allergy have been reported. Our objectives were to describe the outcome of quinolone skin and challenge tests in patients consulting because of a history of adverse reaction to quinolone and to compare the outcome of quinolone skin tests and challenge tests in the subsample of patients who had undergone both tests. METHODS: We reviewed skin and challenge test results of all patients who consulted at our allergy service over the last 5 years because of a history of quinolone adverse reaction in the form of urticaria or anaphylaxis within 1 hour of drug intake (group 1), urticaria or maculopapular eruption between 1 and 24 hours after intake (group 2) or after 24 hours had passed (group 3), or atypical symptoms (group 4). RESULTS: A total of 71 cases were identified: 27, 8, 24 and 12 in groups 1 through 4, respectively. Skin tests were performed in all patients, with positive results in 31 patients. In group 1, 62.9 % of these patients showed positive skin tests and 22.2% showed positive challenge tests, whereas in the other 3 groups, about 30% of patients had positive skin tests and a variable percentage (from 0% to 4.1% depending on the group) had positive challenge tests. Quinolone challenge tests were performed in 10 patients with positive skin tests (5 of them with positive results) and in 34 patients with negative skin tests (2 of them with positive results). CONCLUSIONS: A highly suggestive history of quinolone allergy is more frequently associated with positive skin tests and positive challenge tests. Therefore, skin tests help to predict the result of the challenge test.
Subject(s)
Anti-Infective Agents/adverse effects , Drug Hypersensitivity/diagnosis , Quinolones/adverse effects , Adult , Aged , Aged, 80 and over , Cross Reactions , Female , Humans , Male , Middle Aged , Retrospective Studies , Skin TestsABSTRACT
We are discussing two patients, with clinically compatible reactions, who display an immediate hypersensitive mechanism following the administration of oxaliplatin, confirmed by the performance of cutaneous tests.
Subject(s)
Anaphylaxis/etiology , Antineoplastic Agents/adverse effects , Organoplatinum Compounds/adverse effects , Adult , Antineoplastic Agents/immunology , Colonic Neoplasms/drug therapy , Female , Humans , Male , Organoplatinum Compounds/immunology , OxaliplatinABSTRACT
Anisakis simplex is a nematode which parasitizes mainly fish and cephalopods and accidentally human beings after ingestion. Apart from the different digestive syndromes, this organism has recently been involved as cause of IgE-mediated allergic reactions of variable degree (urticaria to severe angioedema). In this report three patients with the diagnosis of allergy to Anisakis simplex are reported and a review of the literature is made.
Subject(s)
Anisakis/immunology , Urticaria/parasitology , Adult , Animals , Female , Humans , Male , Middle AgedABSTRACT
We present two cases of cutaneous erythroderma induced by carbamazepine therapy, both cases with just cutaneous affection and only one suspicious drug. A cutaneous patch study, with standard battery from the Spanish Contact Dermatitis Research Group, vaseline with carbamazepine at 10% and lectures at 48 and 96 hours, was conducted. The result was positive for carbamazepine and negative for all other patches in both cases. All controls were negative. This is a very simple test, easy to perform, specific and with low side effects, allowing the diagnosis of this pathology.
Subject(s)
Carbamazepine/adverse effects , Dermatitis, Exfoliative/chemically induced , Dermatitis, Exfoliative/diagnosis , Patch Tests , Adult , Female , Humans , Male , Middle AgedABSTRACT
La obstruccion reversible de las vias aereas como consecuencia de estimulos diversos exige tratamiento inmediato y un profundo y concienzudo estudio de su etiologia, patogenia y factores agravantes, para poder conducir adecuadamente una terapia que mejore el pronostico a largo plazo y la calidad de vida del paciente
Subject(s)
Humans , Asthma , Asthma/diagnosis , Asthma/physiopathology , Asthma/prevention & control , Asthma/therapyABSTRACT
Urticaria y angioedema son un problema clinico muy frecuente, cuyos mecanismos patogenicos pueden ser o no inmunologicos y precisan de un diagnostico cuidadoso para identificar las causas desencadenantes.
