Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Type of study
Language
Publication year range
1.
Nat Commun ; 14(1): 5529, 2023 09 08.
Article in English | MEDLINE | ID: mdl-37684243

ABSTRACT

Immune checkpoint inhibitors cause side effects ranging from autoimmune endocrine disorders to severe cardiotoxicity. Periodic Fasting mimicking diet (FMD) cycles are emerging as promising enhancers of a wide range of cancer therapies including immunotherapy. Here, either FMD cycles alone or in combination with anti-OX40/anti-PD-L1 are much more effective than immune checkpoint inhibitors alone in delaying melanoma growth in mice. FMD cycles in combination with anti-OX40/anti-PD-L1 also show a trend for increased effects against a lung cancer model. As importantly, the cardiac fibrosis, necrosis and hypertrophy caused by immune checkpoint inhibitors are prevented/reversed by FMD treatment in both cancer models whereas immune infiltration of CD3+ and CD8+ cells in myocardial tissues and systemic and myocardial markers of oxidative stress and inflammation are reduced. These results indicate that FMD cycles in combination with immunotherapy can delay cancer growth while reducing side effects including cardiotoxicity.


Subject(s)
Drug-Related Side Effects and Adverse Reactions , Lung Neoplasms , Animals , Mice , Cardiotoxicity , Immune Checkpoint Inhibitors/adverse effects , Fasting , Diet , Immunotherapy/adverse effects , Lung Neoplasms/therapy , Myocardium
SELECTION OF CITATIONS
SEARCH DETAIL
...